The Role of Central Sensitization in Autoimmune Connective Tissue Diseases: A Comparative Cross-Sectional Study

IF 2.4 4区医学 Q2 RHEUMATOLOGY

International Journal of Rheumatic Diseases Pub Date : 2025-01-21 DOI:10.1111/1756-185X.70069

Zilan Bazancir-Apaydin, Hakan Apaydin, Berkan Armagan, Kevser Orhan, Sukran Erten

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引用次数: 0

Abstract

Objective

To investigate the central sensitization (CS) in patients with autoimmune connective tissue diseases (ACTDs) and its relationship with disease activity, laboratory findings, medical treatments, organ involvements, and comorbidity.

Methods

One hundred and eleven patients with ACTDs and 40 healthy individuals were included. All patients were divided into three groups in terms of their diseases: Sjögren's syndrome (SS), rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE). The CS was assessed using the central sensitization inventory (CSI-A and CSI-B scores). The disease activity, laboratory findings, medical treatments, organ involvements, and comorbidity of all patients were evaluated.

Results

Overall, 41.4% patients with ACTDs had CS. SS group had the highest CS positivity (n = 21, 58.3%) compared to the RA (n = 14, 36.8%) and SLE (n = 11, 29.7%) groups. The SS group had a significantly higher CSI-A score (p < 0.016) than the RA and SLE group, which had similar scores. CSI-A (p = 0.008, r = −0.63) and CSI-B (p = 0.001, r = −0.76) scores were moderately to high correlated with vitamin D3 levels in SLE group. CSI-B score was moderately correlated with folic acid levels (p = 0.03, r = 0.50) and TSH (p = 0.005, r = 0.55) in SS group. The CSI-A score ≥ 40 subgroup had more female gender, frequency of COPD or asthma, more coexisting fibromyalgia, higher VAS score, more common exocrine gland involvement, and higher corticosteroid dose compared to the CSI score < 40 subgroup.

Conclusions

CS is commonly seen in patients with ACTDs, especially in SS. CS is associated with vitamin D3, folic acid, and TSH levels in ACTD subgroups and the patients with clinical CS have a specific profile.

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中枢致敏在自身免疫性结缔组织疾病中的作用：一项比较横断面研究

目的：探讨自身免疫性结缔组织病（ACTDs）患者的中枢致敏（CS）及其与疾病活动性、实验室检查、药物治疗、器官受累和合并症的关系。方法：纳入111例ACTDs患者和40例健康人。所有患者根据疾病分为三组：Sjögren综合征（SS）、类风湿性关节炎（RA）和系统性红斑狼疮（SLE）。CS采用中心致敏量表（CSI-A和CSI-B评分）评估。评估所有患者的疾病活动性、实验室结果、药物治疗、器官累及及合并症。结果：总体而言，41.4%的ACTDs患者有CS。SS组CS阳性率（n = 21, 58.3%）高于RA组（n = 14, 36.8%）和SLE组（n = 11, 29.7%）。结论：CS常见于ACTD患者，尤其是SS患者。CS与ACTD亚组中维生素D3、叶酸和TSH水平相关，临床CS患者具有特异性。

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来源期刊

International Journal of Rheumatic Diseases RHEUMATOLOGY-

CiteScore

3.70

自引率

4.00%

发文量

362

审稿时长

1 months

期刊介绍： The International Journal of Rheumatic Diseases (formerly APLAR Journal of Rheumatology) is the official journal of the Asia Pacific League of Associations for Rheumatology. The Journal accepts original articles on clinical or experimental research pertinent to the rheumatic diseases, work on connective tissue diseases and other immune and allergic disorders. The acceptance criteria for all papers are the quality and originality of the research and its significance to our readership. Except where otherwise stated, manuscripts are peer reviewed by two anonymous reviewers and the Editor.