Role of Gluten-Free Diet on HbA1c Level in Children with Type 1 Diabetes Mellitus and Celiac Disease.

IF 2.1 Q3 ENDOCRINOLOGY & METABOLISM

International Journal of Endocrinology and Metabolism Pub Date : 2024-09-29 eCollection Date: 2024-07-01 DOI:10.5812/ijem-144736

Hedieh Saneifard, Ali Sheikhy, Aida Fallahzadeh, Marjan Shakiba, Maryam Kazemi Aghdam, Asieh Mosallanejad

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引用次数: 0

Abstract

Background: Due to autoimmune mechanisms, celiac disease (CD) may affect patients with type 1 diabetes mellitus (T1DM) more than the general population.

Objectives: We evaluated the effect of a gluten-free diet (GFD) on HbA1c levels in patients with both type 1 diabetes and CD.

Methods: In this cross-sectional study, biochemical and clinical information was gathered from 174 children with T1DM from January 2013 to January 2019.

Results: We assessed 174 children with T1DM (93 girls and 81 boys). Celiac disease was diagnosed in 18 out of 174 cases (10.34%). Height and weight percentiles showed significant differences between children with CD and those without CD (P = 0.015 and P = 0.026, respectively). The average HbA1c in the celiac group was 8.61 ± 2.20 (95% CI: 5.1 - 12.1) prior to GFD therapy. HbA1c was assessed six and twelve months following the initiation of the GFD and was found to be 8.32 ± 1.46 (95% CI: 6 - 9.8) and 8.37 ± 1.67 (95% CI: 6.1 - 10.2), respectively. No significant change in HbA1c was observed before and after therapy (P = 0.501).

Conclusions: Diabetic children with CD exhibit lower weight and height compared to those without CD. Gluten-free diet therapy in patients with CD did not affect HbA1c levels.

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无麸质饮食对1型糖尿病和乳糜泻儿童HbA1c水平的影响

背景：由于自身免疫机制，乳糜泻（CD）对1型糖尿病（T1DM）患者的影响可能大于一般人群。目的：我们评估无麸质饮食（GFD）对1型糖尿病和cd患者HbA1c水平的影响。方法：在这项横断面研究中，收集了2013年1月至2019年1月期间174名T1DM儿童的生化和临床信息。结果：我们评估了174名T1DM儿童（93名女孩，81名男孩）。174例中有18例（10.34%）被诊断为乳糜泻。CD患儿与非CD患儿的身高和体重百分位数差异有统计学意义（P = 0.015和P = 0.026）。在GFD治疗前，乳糜泻组的平均HbA1c为8.61±2.20 （95% CI: 5.1 - 12.1）。在GFD开始后6个月和12个月评估HbA1c，分别为8.32±1.46 （95% CI: 6 - 9.8）和8.37±1.67 （95% CI: 6.1 - 10.2）。治疗前后HbA1c无明显变化（P = 0.501）。结论：与没有乳糜泻的糖尿病儿童相比，患有乳糜泻的糖尿病儿童表现出较低的体重和身高。乳糜泻患者的无麸质饮食治疗不影响HbA1c水平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Journal of Endocrinology and Metabolism ENDOCRINOLOGY & METABOLISM-

CiteScore

3.10

自引率

4.80%

发文量

期刊介绍： The aim of the International Journal of Endocrinology and Metabolism (IJEM) is to increase knowledge, stimulate research in the field of endocrinology, and promote better management of patients with endocrinological disorders. To achieve this goal, the journal publishes original research papers on human, animal and cell culture studies relevant to endocrinology.