Tissue-Resident Memory T Cells in Tumor Immunity and Immunotherapy of Digestive System Tumors.

IF 2.9 4区医学 Q3 IMMUNOLOGY

Immunological Investigations Pub Date : 2025-01-22 DOI:10.1080/08820139.2024.2447780

Min Cheng, Jie Liu, Yue Liang, Jiamei Xu, Lin Ma, Jing Liang

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引用次数: 0

Abstract

Background: Tissue-resident memory T (TRM) cells possess unique abilities to migrate, establish themselves in tissues, and monitor peripheral tissues without circulating. They are crucial in providing long-lasting and local immune protection against surface infections. TRMs demonstrate distinct phenotypic and functional characteristics compared to central memory T (Tcm) cells and effector memory T (Tem) cells.Methods: We reviewed a large number of literature to explore the physiological and functional roles of tissue-resident memory T cells, as well as the link between TRM cells and the development and prognosis of digestive tract tumors. We also investigated the association between TRM cells, intestinal flora, and metabolites.Results: Recent studies have implicated TRMs in the immune response against tumors, making them a potential target for cancer therapy. However, research specifically focused on gastrointestinal tumors is limited.Conclusion: This review aims to compile and assess the most recent data on the role of TRM cells in gastrointestinal tumor immunity. Additionally, it explores recent advancements in immunotherapy and investigates how TRMs may influence intestinal flora and metabolites.

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组织驻留记忆T细胞在肿瘤免疫和消化系统肿瘤免疫治疗中的作用。

背景：组织常驻记忆T （TRM）细胞具有独特的迁移能力，在组织中建立自己，并监测外周组织而不循环。它们在提供针对表面感染的持久和局部免疫保护方面至关重要。与中枢记忆T细胞（Tcm）和效应记忆T细胞（Tem）相比，TRMs表现出不同的表型和功能特征。方法：通过查阅大量文献，探讨组织常驻记忆T细胞在消化道肿瘤中的生理和功能作用，以及TRM细胞与消化道肿瘤发生、预后的关系。我们还研究了TRM细胞、肠道菌群和代谢物之间的关系。结果：最近的研究表明，TRMs与肿瘤的免疫反应有关，使其成为癌症治疗的潜在靶点。然而，专门针对胃肠道肿瘤的研究是有限的。结论：本综述旨在整理和评价TRM细胞在胃肠道肿瘤免疫中作用的最新数据。此外，它还探讨了免疫治疗的最新进展，并研究了TRMs如何影响肠道菌群和代谢物。

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来源期刊

Immunological Investigations 医学-免疫学

CiteScore

5.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Disseminating immunological developments on a worldwide basis, Immunological Investigations encompasses all facets of fundamental and applied immunology, including immunohematology and the study of allergies. This journal provides information presented in the form of original research articles and book reviews, giving a truly in-depth examination of the latest advances in molecular and cellular immunology.