Histogram of Apparent Diffusion Coefficient to Evaluate the Activity of Thyroid-Associated Ophthalmopathy

IF 3.1 4区医学 Q3 IMMUNOLOGY

Immunity, Inflammation and Disease Pub Date : 2025-01-21 DOI:10.1002/iid3.70131

Defu Li, Tingting Zhu, Yujin Wang

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引用次数: 0

Abstract

Objective

This study aimed to evaluate the activity of extraocular muscles (EOMs) in patients with thyroid-associated ophthalmopathy (TAO) using turbo spin echo imaging. By analyzing tissue heterogeneity, apparent diffusion coefficient (ADC) histogram analysis offers enhanced insights into edema within the EOMs.

Methods

Eighty-eight patients with TAO were retrospectively evaluated and allocated into active (n = 24, clinical activity score [CAS] ≥ 3) and inactive (n = 64, CAS < 3) groups. The parameter values of the ADC histogram of EOMs were measured; the efficacy of ADC histograms in distinguishing between TAO activity and inactivity was assessed using receiver operating characteristic curves. Multifactorial logistic regression was used to determine active TAO predictors.

Results

The minimum, maximum, median, mean; and 1st, 5th, 10th, 25th, 75th, 90th, 95th, and 99th percentiles of the ADC histograms were higher in patients with active than that in participants with inactive TAO. The area under the curve (AUC) of the 10th percentile of the ADC histogram and the median distinguishing between active and inactive TAOs were both 0.791 (both p < 0.05), and the AUCs of the combined model of age, sex, smoking, and the 10th percentile in the ADC histogram were better than those of their individual models and the combined model of age, sex, and smoking (all p < 0.05). Smoking and male sex, along with the median > 1.26 μm²/s, entropy > 4.03, and standard deviation (SD) > 0.4 of the ADC histogram, were significant predictors of TAO activity, with odds ratios of 2.741 and 6.806, 5.070, 2.652, and 2.197, respectively (all p < 0.05).

Conclusion

ADC histograms provide a new method for distinguishing active from inactive TAO, and the 10th percentile enhances the clinical diagnosis of active TAO. In addition to male sex and smoking, an ADC histogram median > 1.26 μm²/s, entropy > 4.03, or SD > 0.4 may also predict active TAO.

Abstract Image

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视扩散系数直方图评价甲状腺相关性眼病活动性。

目的：本研究旨在利用涡轮自旋回波成像技术评价甲状腺相关性眼病（TAO）患者眼外肌（EOMs）的活动性。通过分析组织异质性，表观扩散系数（ADC）直方图分析可以更好地了解EOMs内的水肿。方法：回顾性评价88例TAO患者并将其分为活动期（n = 24，临床活动度评分[CAS]≥3）和非活动期（n = 64， CAS）。活动期TAO患者ADC直方图的第1、5、10、25、75、90、95、99百分位均高于非活动期TAO患者。ADC直方图的曲线下面积（AUC）和活性TAOs与非活性TAOs的中位数差异均为0.791 （p均为1.26 μm2/s，熵值为4.03，标准差（SD）为0.4）是TAO活性的显著预测因子，比值比分别为2.741、6.806、5.070、2.652、2.197（均p）。ADC直方图为区分活动性和非活动性TAO提供了一种新的方法，第10百分位提高了活动性TAO的临床诊断。除男性和吸烟外，ADC直方图中位数> 1.26 μm²/s、熵> 4.03或SD > 0.4也可预测活动性TAO。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Immunity, Inflammation and Disease Medicine-Immunology and Allergy

CiteScore

3.60

自引率

0.00%

发文量

146

审稿时长

8 weeks

期刊介绍： Immunity, Inflammation and Disease is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research across the broad field of immunology. Immunity, Inflammation and Disease gives rapid consideration to papers in all areas of clinical and basic research. The journal is indexed in Medline and the Science Citation Index Expanded (part of Web of Science), among others. It welcomes original work that enhances the understanding of immunology in areas including: • cellular and molecular immunology • clinical immunology • allergy • immunochemistry • immunogenetics • immune signalling • immune development • imaging • mathematical modelling • autoimmunity • transplantation immunology • cancer immunology