Prevalence and Bidirectional Association Between Primary Sclerosing Cholangitis and Crohn's disease: A Systematic Review and Meta-Analysis.

IF 2.2 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Gastroenterologia y hepatologia Pub Date : 2025-01-18 DOI:10.1016/j.gastrohep.2025.502346

Dongyuan Zheng, Xu Qinke, Wu Jin, Gu Zhouyue, Jieya Chen, Yingchao Liu

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引用次数: 0

Abstract

Purpose: This meta-analysis aimed to evaluating the prevalence of Crohn's disease in primary sclerosing cholangitis (PSC) and the incidence of primary sclerosing cholangitis in Crohn's disease (CD), along with their interrelation.

Methods: An extensive search was conducted in the PubMed and Embase to identify available publications up to December 2023. Studies were included if they reported the prevalence of CD in PSC patients, or vice versa. Proportions were assessed using the DerSimonian and Laird method, followed by transformation via the Freeman-Tukey double inverse sine transformation. The quality of the included studies utilizing the Joanna Briggs Institute Critical Appraisal Checklist.

Results: Based on quantitative analysis of 61 studies, the prevalence of PSC in patients with CD was 0.88% (95% CI: 0.53%-1.30%). The prevalence of PSC in male CD patients was 0.45% (95% CI: 0.03%-1.16%). In female CD patients, the prevalence was 0.51% (95% CI: 0.09%-1.14%). The prevalence of CD with PSC was 11.27% (95% CI: 9.56%-13.10%). The prevalence of CD in male PSC patients was 10.71% (95% CI: 7.42%-14.50%). Among female PSC patients, the pooled prevalence of CD was 13.05% (95% CI: 11.05%-15.19%).

Conclusions: We found a significant bidirectional association between PSC and CD, with a higher prevalence of CD in female with PSC compared to male. These findings provide important epidemiological data for clinical practice.

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目的：本荟萃分析旨在评估克罗恩病在原发性硬化性胆管炎（PSC）中的患病率和克罗恩病（CD）中原发性硬化性胆管炎的发病率及其相互关系。方法：在PubMed和Embase中进行了广泛的搜索，以确定截至2023年12月的可用出版物。如果研究报告了PSC患者中CD的患病率，则纳入研究，反之亦然。使用DerSimonian和Laird方法评估比例，然后通过Freeman-Tukey双重反正弦变换进行变换。使用乔安娜布里格斯研究所关键评估清单的纳入研究的质量。结果：基于61项研究的定量分析，CD患者PSC患病率为0.88% （95% CI: 0.53%-1.30%）。男性CD患者中PSC的患病率为0.45% （95% CI: 0.03%-1.16%）。在女性CD患者中，患病率为0.51% （95% CI: 0.09%-1.14%）。CD合并PSC的患病率为11.27% （95% CI: 9.56%-13.10%）。男性PSC患者CD患病率为10.71% （95% CI: 7.42%-14.50%）。在女性PSC患者中，CD的总患病率为13.05% （95% CI: 11.05%-15.19%）。结论：我们发现PSC和CD之间存在显著的双向关联，女性PSC患者的CD患病率高于男性。这些发现为临床实践提供了重要的流行病学资料。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Gastroenterologia y hepatologia GASTROENTEROLOGY & HEPATOLOGY-

CiteScore

1.50

自引率

10.50%

发文量

147

审稿时长

48 days

期刊介绍： Gastroenterology and Hepatology is the first journal to cover the latest advances in pathology of the gastrointestinal tract, liver, pancreas, and bile ducts, making it an indispensable tool for gastroenterologists, hepatologists, internists and general practitioners.