Effect of e-cigarettes for smoking cessation on depressive and anxiety symptoms: Secondary analysis of a randomized controlled trial

IF 4.1 2区医学 Q1 PSYCHIATRY

General hospital psychiatry Pub Date : 2025-01-16 DOI:10.1016/j.genhosppsych.2025.01.011

Anna Rihs , Anna Schoeni , Tamara Scharf , Julian Jakob , Kali Tal , Isabelle Jacot-Sadowski , Jean-Paul Humair , Anja Frei , Martin Brutsche , Nicolas Rodondi , Reto Auer , Stéphanie Baggio

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引用次数: 0

Abstract

Objective

This study aims to assess differences in depressive and anxiety symptoms at 6-month follow-up in a smoking cessation trial using e-cigarettes as quitting aids.

Methods

We conducted a secondary analysis of the Swiss multicentre ESTxENDS smoking cessation randomized controlled trial (RCT) assessing differences in depressive (Patient Health Questionnaire-9, PHQ-9, range: 0–27) and anxiety symptoms (General Anxiety Disorder-7, GAD-7, range: 0–21) at 6-month follow-up comparing participants who received e-cigarettes to those who received smoking cessation counseling alone.

Results

Of 1244 participants 913 completed the PHQ-9 and 884 the GAD-7 at 6-month follow-up. Mean PHQ-9 scores (SD) at 6 months for the intervention group were 3.7 (3.9), control group: 4.0 (4.2); mean GAD-7 scores (SD) at 6 months for the intervention group were 4.6 (4.3), control group: 4.6 (4.4). Multivariable analyses showed no evidence of a clinically relevant intervention effect on the PHQ-9 [coefficient − 0.101, 95 % CI -0.182 to −0.019, p = .016, corresponding to a 0.9 decrease of the original PHQ-9 score] and the GAD-7 scores [coefficient − 0.056, 95 % CI -0.135 to 0.022, p = .160] in the main adjusted models.

Conclusions

Among smokers who participated in the ESTxENDS smoking cessation trial, we found distribution of e-cigarettes for smoking cessation in addition to standard counseling compared to counseling alone had no clinically relevant effect on depressive or anxiety symptoms at 6-month follow-up.

Trial Registration: ClinicalTrials NCT03603340

查看原文本刊更多论文

电子烟戒烟对抑郁和焦虑症状的影响：一项随机对照试验的二次分析。

目的：本研究旨在评估使用电子烟作为戒烟辅助的戒烟试验中6个月随访期间抑郁和焦虑症状的差异。方法：我们对瑞士多中心ESTxENDS戒烟随机对照试验（RCT）进行了二次分析，评估在6个月的随访中，接受电子烟治疗的参与者与单独接受戒烟咨询的参与者在抑郁（患者健康问卷-9，PHQ-9，范围：0-27）和焦虑症状（一般焦虑障碍-7，GAD-7，范围：0-21）方面的差异。结果：在6个月的随访中，1244名参与者中913名完成了PHQ-9, 884名完成了GAD-7。干预组6个月平均PHQ-9评分（SD） 3.7分（3.9分），对照组4.0分（4.2分）；干预组6个月时GAD-7平均评分（SD） 4.6分（4.3分），对照组4.6分（4.4分）。多变量分析显示，在主要调整模型中，没有证据表明临床相关干预对PHQ-9[系数- 0.101,95% CI -0.182至-0.019,p = 0.016，对应于原始PHQ-9评分降低0.9]和GAD-7评分[系数- 0.056,95% CI -0.135至0.022,p = 0.160]有影响。结论：在参加ESTxENDS戒烟试验的吸烟者中，我们发现在6个月的随访中，在标准咨询的基础上分发戒烟电子烟与单独咨询相比，对抑郁或焦虑症状没有临床相关的影响。试验注册：ClinicalTrials NCT03603340。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

General hospital psychiatry 医学-精神病学

CiteScore

9.60

自引率

2.90%

发文量

125

审稿时长

20 days

期刊介绍： General Hospital Psychiatry explores the many linkages among psychiatry, medicine, and primary care. In emphasizing a biopsychosocial approach to illness and health, the journal provides a forum for professionals with clinical, academic, and research interests in psychiatry''s role in the mainstream of medicine.