Advances in soft nanoparticle-based platforms for human and veterinary trichomoniasis therapy: A scoping review.

IF 4.4 2区医学 Q1 PHARMACOLOGY & PHARMACY

European Journal of Pharmaceutics and Biopharmaceutics Pub Date : 2025-01-18 DOI:10.1016/j.ejpb.2025.114638

Raul Edison Luna Lazo, Fernando Miguel Stelmach Alves, Eric Luiz Domingos, Alexandre de Fatima Cobre, Paulo Vitor Farago, Letícia Cruz, Tiana Tasca, Roberto Pontarolo, Luana Mota Ferreira

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引用次数: 0

Abstract

This scoping review focuses on drug delivery systems based on soft materials designed for the administration of drugs with anti-Trichomonas vaginalis activity. It primarily examines their use in addressing human trichomoniasis, exploring their physicochemical characteristics, in vitro and in vivo evaluation and identifying existing challenges and gaps. Given the economic burden and the One Health approach, formulations developed aiming at treating animal infections - cattle and poultry - were also discussed. The review involved searching electronic databases, such as PubMed, Scopus, and Web of Science, to find studies published until May 2024; out of the 103 articles retrieved, 18 fulfilled the eligibility criteria. This study investigated soft-nanoparticle formulations, including polymericand lipid-based systems, and their incorporation into suitable formulations for topical application, including hydrogels and polymeric films. Additionally, the discussion covered toxicology and highlighted the knowledge gaps related to the potential use of these formulations in humans. Anti-trichomonas soft nano-based formulations emerge as promising candidates for treating gynecological and animal infections. In conclusion, further preclinical testing is necessary, as none of the formulations have progressed to human clinical trials and have only been evaluated in animal models.

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基于软纳米颗粒的人类和兽医滴虫病治疗平台的进展：范围综述。

本文综述了基于软质材料的给药系统的研究进展，该系统设计用于抗阴道毛滴虫活性药物的给药。它主要审查它们在解决人类滴虫病方面的应用，探索其物理化学特性，体外和体内评估，并确定现有的挑战和差距。考虑到经济负担和“同一个健康”方针，还讨论了旨在治疗动物感染（牛和家禽）的方案。审查涉及搜索电子数据库，如PubMed， Scopus和Web of Science，以查找发表到2024年5月的研究；在检索到的103篇文章中，有18篇符合资格标准。本研究研究了软纳米颗粒配方，包括聚合物和基于脂质的系统，以及它们与局部应用的合适配方的结合，包括水凝胶和聚合物薄膜。此外，讨论还涉及毒理学，并强调了与这些制剂在人类中的潜在用途有关的知识差距。抗毛滴虫软纳米基制剂成为治疗妇科和动物感染的有希望的候选者。总之，进一步的临床前测试是必要的，因为没有一种配方已经发展到人体临床试验，只在动物模型中进行了评估。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

European Journal of Pharmaceutics and Biopharmaceutics 医学-药学

CiteScore

8.80

自引率

4.10%

发文量

211

审稿时长

36 days

期刊介绍： The European Journal of Pharmaceutics and Biopharmaceutics provides a medium for the publication of novel, innovative and hypothesis-driven research from the areas of Pharmaceutics and Biopharmaceutics. Topics covered include for example: Design and development of drug delivery systems for pharmaceuticals and biopharmaceuticals (small molecules, proteins, nucleic acids) Aspects of manufacturing process design Biomedical aspects of drug product design Strategies and formulations for controlled drug transport across biological barriers Physicochemical aspects of drug product development Novel excipients for drug product design Drug delivery and controlled release systems for systemic and local applications Nanomaterials for therapeutic and diagnostic purposes Advanced therapy medicinal products Medical devices supporting a distinct pharmacological effect.