Daily executive functioning in adults with pediatric hemispherectomy

IF 2 4区医学 Q3 CLINICAL NEUROLOGY

Epilepsy Research Pub Date : 2025-02-01 DOI:10.1016/j.eplepsyres.2025.107509

Cory E. Kowalski , Warren S. Brown , Anne A.T. Nolty , Amanda Panos , Monika Jones , Lynn K. Paul

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引用次数: 0

Abstract

Background and aims

For young children with intractable epilepsy caused by congenital abnormalities or acquired cortical lesions, pediatric hemispherectomy surgery (pHS) may offer the only path to seizure remediation. Although some sensory and motor outcomes of pHS are highly predictable, the long-term cognitive and functional sequelae of pHS are far more variable. With the aim of identifying potential post-pHS intervention targets, the current study examined daily executive functioning and self-awareness in adults with pHS and broadly intact cognitive outcomes (indicated by average or above performance on intelligence tests).

Methods

This study used self- and informant-ratings on the Behavior Rating Inventory of Executive Functioning, Adult Version (BRIEF-A) everyday executive functioning in to evaluate adaptive behavior in 16 adults with pHS and Full-Scale IQ (FSIQ) of 77 or greater. Self- and informant-report results were compared to the normative sample, as was the proportion of participants with self vs. informant discrepancy scores of > 1 standard deviation.

Results

Both participants and informants reported each participants’ behaviors and executive functioning were largely commensurate with average range from test norms. On average, participants with pHS rated themselves as stronger than their peers at Self-Monitoring, possibly suggesting compensatory attention to issues surrounding their sensory-motor disabilities (e.g., hemiplegia and hemianopsia). Informant- and self-reports were generally consistent, with the exception of an elevated number of participants whose self-ratings indicated less impairment than informant-ratings on the Initiate subscale.

Conclusions

This study demonstrates that following pHS, adults with average (or higher) general cognition also exhibit daily executive functioning broadly commensurate with their peers, with the possible exceptions of elevated self-monitoring and greater likelihood of overestimating their initiation (compared to informant ratings).

查看原文本刊更多论文

儿童半脑切除术后成人日常执行功能的变化。

背景和目的：对于由先天性异常或获得性皮质病变引起的顽固性癫痫患儿，儿科半球切除术（pHS）可能是癫痫发作补救的唯一途径。虽然小灵通的一些感觉和运动结果是高度可预测的，但小灵通的长期认知和功能后遗症则更加多变。为了确定潜在的pHS后干预目标，本研究检查了pHS成人的日常执行功能和自我意识，以及大致完整的认知结果（通过智力测试的平均或以上表现来表明）。方法：本研究采用《执行功能行为评定量表成人版（BRIEF-A）》中的自我评定和信息提供者评定，对16名小灵通、全面智商（FSIQ）在77及以上的成年人的适应行为进行评估。自我和举报人报告的结果与规范样本进行比较，自我与举报人差异分数为> 1标准差的参与者比例也是如此。结果：参与者和举报人都报告每个参与者的行为和执行功能在很大程度上与测试规范的平均范围相称。平均而言，有小灵通的参与者认为自己在自我监控方面比同龄人更强，这可能表明他们对感觉运动障碍（例如偏瘫和偏盲）的问题给予了补偿性关注。举报人的报告和自我报告总体上是一致的，除了一些参与者的自我评分比举报人在启动子量表上的评分显示更少的损害。结论：本研究表明，在ph值之后，具有平均（或更高）一般认知能力的成年人也表现出与同龄人大致相当的日常执行功能，除了自我监控水平升高和更有可能高估自己的开始（与信息提供者评分相比）。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Epilepsy Research 医学-临床神经学

CiteScore

0.10

自引率

4.50%

发文量

143

审稿时长

62 days

期刊介绍： Epilepsy Research provides for publication of high quality articles in both basic and clinical epilepsy research, with a special emphasis on translational research that ultimately relates to epilepsy as a human condition. The journal is intended to provide a forum for reporting the best and most rigorous epilepsy research from all disciplines ranging from biophysics and molecular biology to epidemiological and psychosocial research. As such the journal will publish original papers relevant to epilepsy from any scientific discipline and also studies of a multidisciplinary nature. Clinical and experimental research papers adopting fresh conceptual approaches to the study of epilepsy and its treatment are encouraged. The overriding criteria for publication are novelty, significant clinical or experimental relevance, and interest to a multidisciplinary audience in the broad arena of epilepsy. Review articles focused on any topic of epilepsy research will also be considered, but only if they present an exceptionally clear synthesis of current knowledge and future directions of a research area, based on a critical assessment of the available data or on hypotheses that are likely to stimulate more critical thinking and further advances in an area of epilepsy research.