Effects and Safety of Botulinum Toxin Injection in Treatment of Androgenetic Alopecia: A Meta-analysis and Systematic Review.

IF 2.5 3区医学 Q2 DERMATOLOGY

Dermatologic Surgery Pub Date : 2025-01-22 DOI:10.1097/DSS.0000000000004557

Fengrui Cheng, Xingrui Cai, Ying Zhang, Jingping Wu, Sisi Yin

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引用次数: 0

Abstract

Background: Androgenetic alopecia (AGA) is a prevalent condition that significantly affects the psychosocial well-being of many individuals, and its treatment remains a clinical challenge. Botulinum toxin (BTX) injections have been reported to have a therapeutic effect on AGA. Although several studies have explored the efficacy and safety of this novel treatment, most are clinical studies with small sample sizes.

Objective: To evaluate the efficacy and safety of BTX injections in the treatment of AGA through a meta-analysis and systematic review.

Methods: A comprehensive literature search was conducted using PubMed, EMBASE, the Cochrane Central Register of Controlled Trials, ScienceDirect, Springer, and Web of Science to identify studies investigating the use of BTX in the treatment of AGA. The primary outcome was hair count.

Results: Eight studies were included in the systematic review. The pooled data demonstrated a statistically significant increase in hair count in patients treated with BTX compared with the control group (standardized mean difference = 1.02; 95% confidence interval, 0.30-1.74, p < .05).

Conclusion: Injectable BTX seems to be a promising treatment for AGA, showing significant efficacy and good safety.

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注射肉毒毒素治疗雄激素性脱发的疗效和安全性：荟萃分析和系统评价。

背景：雄激素性脱发（AGA）是一种普遍的疾病，显著影响许多个体的社会心理健康，其治疗仍然是一个临床挑战。据报道，注射肉毒杆菌毒素（BTX）对AGA有治疗作用。虽然有几项研究探讨了这种新疗法的有效性和安全性，但大多数都是小样本量的临床研究。目的：通过荟萃分析和系统评价BTX注射液治疗AGA的疗效和安全性。方法：通过PubMed、EMBASE、Cochrane中央对照试验注册库、ScienceDirect、施普林格和Web of Science进行全面的文献检索，以确定调查BTX治疗AGA的研究。主要结果是毛发计数。结果：8项研究被纳入系统评价。汇总数据显示，与对照组相比，接受BTX治疗的患者头发数量有统计学意义的增加(标准化平均差异= 1.02；95%置信区间，0.30-1.74,p < 0.05)。结论：注射BTX治疗AGA疗效显著，安全性好，是一种很有前景的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Dermatologic Surgery 医学-皮肤病学

CiteScore

3.10

自引率

16.70%

发文量

547

期刊介绍： Exclusively devoted to dermatologic surgery, the Dermatologic Surgery journal publishes the most clinically comprehensive and up-to-date information in its field. This unique monthly journal provides today’s most expansive and in-depth coverage of cosmetic and reconstructive skin surgery and skin cancer through peer-reviewed original articles, extensive illustrations, case reports, ongoing features, literature reviews and correspondence. The journal provides information on the latest scientific information for all types of dermatologic surgery including: -Ambulatory phlebectomy- Blepharoplasty- Body contouring- Chemical peels- Cryosurgery- Curettage and desiccation- Dermabrasion- Excision and closure- Flap Surgery- Grafting- Hair restoration surgery- Injectable neuromodulators- Laser surgery- Liposuction- Microdermabrasion- Microlipoinjection- Micropigmentation- Mohs micrographic surgery- Nail surgery- Phlebology- Sclerotherapy- Skin cancer surgery- Skin resurfacing- Soft-tissue fillers. Dermatologists, dermatologic surgeons, plastic surgeons, oculoplastic surgeons and facial plastic surgeons consider this a must-read publication for anyone in the field.