Association of respiratory infections with the incidence and treatment efficacy in Kawasaki disease

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2025-01-13 DOI:10.1016/j.diagmicrobio.2025.116688

Soshi Hachisuka , Taito Kitano , Daisuke Kitagawa , Masayuki Murata , Mai Onishi , Takahiro Mori , Tenshin Okubo , Naohiro Yamamoto , Hiroki Nishikawa , Masayuki Onaka , Rika Suzuki , Madoka Sekine , Soma Suzuki , Fumihiko Nakamura , Sayaka Yoshida

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Abstract

The etiology of Kawasaki disease (KD) has not yet been completely elucidated. We evaluated the temporal association between respiratory pathogens and KD incidence and the association between respiratory pathogens and treatment responsiveness in patients with KD.

This retrospective study was conducted to compare the number of symptomatic children with pathogens detected using multiplex PCR tests with the number of KD cases. Logistic analysis was performed to assess whether the presence of at least one respiratory virus was associated with immunoglobulin non-responsiveness in patients with KD. A statistically significant temporal association was found between the number of KD patients and the number of patients with a positive respiratory pathogen (Pearson correlation coefficient +0.595; p=0.003). The adjusted odds ratio of respiratory pathogen detection for immunoglobulin responsiveness was 1.24 (95% confidence interval 0.38–4.11) (p=0.721). Our study demonstrated a temporal association between the total number of respiratory infections and KD.

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川崎病呼吸道感染与发病率及治疗效果的关系。

川崎病（KD）的病因尚未完全阐明。我们评估了呼吸道病原体与KD发病率之间的时间相关性，以及呼吸道病原体与KD患者治疗反应性之间的相关性。本回顾性研究旨在比较多重PCR检测病原菌的有症状儿童的数量与KD病例的数量。进行Logistic分析以评估是否存在至少一种呼吸道病毒与KD患者免疫球蛋白无反应性相关。KD患者数量与呼吸道病原体阳性患者数量之间存在显著的时间相关性(Pearson相关系数+0.595；p = 0.003)。呼吸道病原体检测对免疫球蛋白反应性的校正优势比为1.24(95%可信区间0.38 ~ 4.11)（p=0.721）。我们的研究表明呼吸道感染总数与KD之间存在时间相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.