The Log_e GDR Was Strongly Associated with NAFLD as a Predictor in Normoalbuminuric Patients with Type 2 Diabetes.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S500739

Baolan Ji, Guanqi Gao, Hongyan Zhao, Jie Sheng, Xuan Ma, Shuwei Shi, Bo Ban

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Abstract

Aim: Attenuated insulin-sensitivity (IS) is a characteristic of type 2 diabetes (T2D) and is closely linked to non-alcoholic fatty liver disease (NAFLD). In recent years, many surrogate markers of IS have emerged to predict NAFLD. A natural log transformation of the glucose disposal rate (log_e GDR) has been proposed as a new model for IS in patients with T2D. Our aim is to explore the correlation between log_e GDR and NAFLD in normoalbuminuric patients with T2D.

Methods: A total of 1227 normoalbuminuric patients with T2D were involved in our study. NAFLD was evaluated by ultrasound. Biochemical and clinical data were collected, including parameters essential for calculating the log_e GDR (triglycerides, urinary albumin-to-creatinine ratio, γ-glutamyl transferase and body mass index), as well as other relevant covariates required for adjustment. The relationship between the log_e GDR and NAFLD was analyzed.

Results: NAFLD patients showed lower log_e GDR values than non-NAFLD (P < 0.001). As the log_e GDR tertiles increased, the prevalence of NAFLD was decreased (P < 0.001). Multivariate analysis displayed that log_e GDR was independently corrected with NAFLD (OR: 0.084; 95% CI: 0.040-0.177). Furthermore, receiver operating characteristic (ROC) analysis showed that log_e GDR (area under the curves: 0.797) was superior to other evaluation variables.

Conclusion: The log_e GDR was strongly associated with NAFLD and might be a useful predictor in normoalbuminuric patients with T2D.

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作为2型糖尿病正常蛋白尿患者的预测因子，Loge GDR与NAFLD密切相关。

目的：胰岛素敏感性降低（IS）是2型糖尿病（T2D）的一个特征，与非酒精性脂肪性肝病（NAFLD）密切相关。近年来，出现了许多IS的替代标记物来预测NAFLD。葡萄糖处理速率（loge GDR）的自然对数变换已被提出作为T2D患者IS的新模型。我们的目的是探讨低GDR和NAFLD在正常蛋白尿合并t2dm患者中的相关性。方法：对1227例尿白蛋白正常的t2dm患者进行研究。超声检查NAFLD。收集生化和临床数据，包括计算大GDR所需的参数（甘油三酯、尿白蛋白与肌酐比值、γ-谷氨酰转移酶和体重指数），以及需要调整的其他相关协变量。分析低GDR与NAFLD的关系。结果：NAFLD患者的loge GDR值低于非NAFLD （P < 0.001）。随着GDR的增加，NAFLD的患病率降低（P < 0.001）。多因素分析显示，loge GDR与NAFLD独立校正(OR: 0.084；95% ci: 0.040-0.177)。此外，受试者工作特征（ROC）分析显示，loge GDR（曲线下面积：0.797）优于其他评价变量。结论：高GDR与NAFLD密切相关，可能是正常蛋白尿合并T2D患者的有效预测指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.