Association of socioeconomic status with diabetic microvascular complications: a UK Biobank prospective cohort study.

IF 3.4 3区医学 Q2 ENDOCRINOLOGY & METABOLISM

Diabetology & Metabolic Syndrome Pub Date : 2025-01-20 DOI:10.1186/s13098-025-01584-0

Yikeng Huang, Zhi Zheng, Haibing Chen, Chufeng Gu

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引用次数: 0

Abstract

Background: Prior studies on the link between socioeconomic status (SES) and diabetic microvascular complications have been inconclusive. This study aimed to explore whether SES is associated with the risk of diabetic retinopathy (DR), nephropathy (DN) and diabetic peripheral neuropathy (DPN) using large prospective cohort.

Methods: SES was evaluated using education attainment (individual level), household income (household level), and Townsend deprivation index (TDI, neighborhood level). This study included 28,339 participants without DR, 29,951 without DN and 29,762 without DPN at baseline from the UK Biobank. Weighted Cox proportional hazard models were used to investigate the relationship between SES and the risk of diabetic microvascular complications.

Results: The median follow-ups of the DR, DN and DPN cohorts were 12.95, 12.89 and 13.02 years, respectively. In total, 3,177 (11.2%) participants developed DR, 4,418 (14.8%) developed DN and 1,604 (5.4%) developed DPN. After adjusting for confounders, higher education levels (DN: hazard ratios [HR] = 0.85; 95% CI, 0.82-0.89; P < 0.001; DPN: HR = 0.93; 95% CI, 0.87-1.00; P = 0.040), higher household income (DN: HR = 0.80; 95% CI, 0.75-0.85; P < 0.001; DPN: HR = 0.80; 95% CI, 0.73-0.89; P < 0.001), and lower TDI (DN: HR = 1.19; 95% CI, 1.14-1.23; P < 0.001; DPN: HR = 1.27; 95% CI, 1.19-1.36; P < 0.001) were associated with a lower risk of DN and DPN. In contrast, a lower risk of DR was only related to higher household income (HR = 0.92; 95% CI, 0.87-0.97; P = 0.004) and lower TDI (HR = 1.08; 95% CI, 1.02-1.13; P = 0.004).

Conclusions: Low SES increases the risk of diabetic microvascular complications, emphasizing the need for equitable medical resource allocation to reduce diabetes-related inequity.

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社会经济地位与糖尿病微血管并发症的关系：英国生物银行前瞻性队列研究

背景：先前关于社会经济地位（SES）与糖尿病微血管并发症之间关系的研究尚无定论。本研究旨在通过大型前瞻性队列研究SES是否与糖尿病视网膜病变（DR）、肾病（DN）和糖尿病周围神经病变（DPN）的风险相关。方法：采用受教育程度（个人水平）、家庭收入（家庭水平）和Townsend剥夺指数（TDI，社区水平）对SES进行评价。该研究包括来自UK Biobank的28,339名无DR， 29,951名无DN和29,762名无DPN的基线参与者。采用加权Cox比例风险模型探讨SES与糖尿病微血管并发症风险的关系。结果：DR、DN和DPN组的中位随访时间分别为12.95年、12.89年和13.02年。总共有3177名（11.2%）参与者发展为DR， 4418名（14.8%）参与者发展为DN， 1604名（5.4%）参与者发展为DPN。调整混杂因素后，高等教育水平(DN：风险比[HR] = 0.85；95% ci, 0.82-0.89；结论：低SES增加了糖尿病微血管并发症的风险，强调需要公平的医疗资源分配以减少糖尿病相关的不公平。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetology & Metabolic Syndrome ENDOCRINOLOGY & METABOLISM-

CiteScore

6.20

自引率

0.00%

发文量

170

审稿时长

7.5 months

期刊介绍： Diabetology & Metabolic Syndrome publishes articles on all aspects of the pathophysiology of diabetes and metabolic syndrome. By publishing original material exploring any area of laboratory, animal or clinical research into diabetes and metabolic syndrome, the journal offers a high-visibility forum for new insights and discussions into the issues of importance to the relevant community.