Comprehensive Review and Meta-Analysis of Psychological and Pharmacological Treatment for Intermittent Explosive Disorder: Insights From Both Case Studies and Randomized Controlled Trials.

IF 3.2 3区心理学 Q1 PSYCHOLOGY, CLINICAL

Clinical psychology & psychotherapy Pub Date : 2025-01-01 DOI:10.1002/cpp.70016

Fangqing Liu, Xiaoshan Yin, Wenting Jiang

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引用次数: 0

Abstract

Intermittent explosive disorder (IED) is characterized by sudden, disproportionate outbursts of anger that can severely impact individuals' quality of life, causing difficulties in maintaining relationships, issues at work or school and potential legal troubles. This study aimed to systematically review and meta-analyse the effectiveness of psychological and pharmacological treatments for IED, drawing insights from both case studies and randomized controlled trials (RCTs). A total of 12 RCTs and 14 case studies were included in this comprehensive analysis. The meta-analysis revealed that psychological treatments, particularly cognitive behavioural therapy (CBT), showed significant effectiveness in reducing aggression and achieving full remission compared to pharmacological treatments. However, the latter, notably fluoxetine, demonstrated notable efficacy in managing irritability and achieving treatment response. Subgroup analysis identified follow-up time and intervention type as significant moderators of treatment outcomes. The systematic review of case studies highlighted the successful application of deep brain stimulation (DBS) and various off-label medications, including SSRIs and mood stabilizers, in managing IED symptoms. Despite these insights, the study emphasizes the need for more robust evidence-based treatment protocols and further research into the underlying mechanisms of IED to develop targeted treatments.

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间歇爆发性精神障碍的心理和药物治疗的综合回顾和荟萃分析：来自病例研究和随机对照试验的见解。

间歇性爆发障碍（IED）的特征是突然的、不成比例的愤怒爆发，这会严重影响个人的生活质量，导致维持人际关系的困难、工作或学校问题以及潜在的法律问题。本研究旨在系统回顾和荟萃分析心理和药物治疗IED的有效性，从案例研究和随机对照试验（RCTs）中获得见解。这项综合分析共纳入了12项随机对照试验和14项病例研究。荟萃分析显示，与药物治疗相比，心理治疗，特别是认知行为治疗（CBT）在减少攻击和实现完全缓解方面显示出显著的有效性。然而，后者，特别是氟西汀，在控制易怒和实现治疗反应方面表现出显着的疗效。亚组分析发现随访时间和干预类型是治疗结果的显著调节因子。对案例研究的系统回顾强调了脑深部刺激（DBS）和各种标签外药物（包括SSRIs和情绪稳定剂）在控制IED症状方面的成功应用。尽管有这些见解，该研究强调需要更强有力的循证治疗方案，并进一步研究IED的潜在机制，以开发有针对性的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical psychology & psychotherapy PSYCHOLOGY, CLINICAL-

CiteScore

6.30

自引率

5.60%

发文量

106

期刊介绍： Clinical Psychology & Psychotherapy aims to keep clinical psychologists and psychotherapists up to date with new developments in their fields. The Journal will provide an integrative impetus both between theory and practice and between different orientations within clinical psychology and psychotherapy. Clinical Psychology & Psychotherapy will be a forum in which practitioners can present their wealth of expertise and innovations in order to make these available to a wider audience. Equally, the Journal will contain reports from researchers who want to address a larger clinical audience with clinically relevant issues and clinically valid research.