Vitamin D deficiency may accelerate cognitive decline in female apolipoprotein E ε4 non-carriers

IF 6.6 2区医学 Q1 NUTRITION & DIETETICS

Clinical nutrition Pub Date : 2025-02-01 DOI:10.1016/j.clnu.2024.12.029

Jiwon Kim , Eunjeong Ji , Jong Bin Bae , Ji Won Han , Tae Hui Kim , Kyung Phil Kwak , Bong Jo Kim , Shin Gyeom Kim , Jeong Lan Kim , Seok Woo Moon , Joon Hyuk Park , Seung-Ho Ryu , Jong Chul Youn , Dong Young Lee , Dong Woo Lee , Seok Bum Lee , Jung Jae Lee , Jin Hyeong Jhoo , Junghan Song , Kyunghoon Lee , Ki Woong Kim

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引用次数: 0

Abstract

Background & aims

The impact of vitamin D deficiency (VDD) on cognition remains controversial. Evidences suggest that variability based on apolipoprotein E (APOE) ε4 status and gender, given APOE ε4's influence on vitamin D metabolism and women's heightened vitamin D sensitivity. We investigated the interplay between APOE ε4, gender, and VDD in cognitive decline among older adults.

Methods

In a population-based cohort of 1547 cognitively normal Koreans aged ≥60 years, Mini Mental State Examination (MMSE) changes were tracked biennially (2010–2020). VDD was defined as serum 25-hydroxyvitamin D < 10 ng/mL. Linear mixed models analyzed VDD effects, with subgroup analyses for APOE ε4 status and gender.

Results

VDD was present in 21.3 % at baseline and was linked to faster MMSE decline (estimate = −0.054, 95 % CI [-0.091, −0.017], p = 0.004), particularly in APOE ε4 non-carriers (estimate = −0.070, 95 % CI [-0.112, −0.029], p = 0.001). A gender-based analysis revealed that this effect was significant only in female non-carriers (estimate = −0.097, 95 % CI [-0.156, −0.038], p = 0.001). Conversely, male non-carriers demonstrated an absence of a statistically significant association (estimate = −0.017, 95 % CI [-0.076, 0.041], p = 0.562).

Conclusions

VDD accelerates cognitive decline in cognitively normal APOE ε4 non-carriers, particularly women, underscoring the importance of tailored prevention strategies.

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维生素D缺乏可能加速女性载脂蛋白E ε4非携带者的认知能力下降。

背景与目的：维生素D缺乏症（VDD）对认知的影响仍存在争议。有证据表明，由于载脂蛋白E (APOE) ε4对维生素D代谢的影响以及女性维生素D敏感性的提高，这种变异基于载脂蛋白E (APOE) ε4状态和性别。我们研究了APOE ε4、性别和VDD在老年人认知能力下降中的相互作用。方法：在1547名年龄≥60岁认知正常的韩国人群为基础的队列中，每两年（2010-2020）追踪一次迷你精神状态检查（MMSE）的变化。结果：基线时VDD发生率为21.3%，与MMSE下降速度加快有关（估计= -0.054,95% CI [-0.091, -0.017], p = 0.004），特别是APOE ε4非携带者（估计= -0.070,95% CI [-0.112, -0.029], p = 0.001）。基于性别的分析显示，这种影响仅在女性非携带者中显著（估计= -0.097,95% CI [-0.156, -0.038], p = 0.001）。相反，男性非携带者显示没有统计学上显著的关联（估计= -0.017,95% CI [-0.076, 0.041], p = 0.562）。结论：VDD加速认知正常APOE ε4非携带者的认知能力下降，特别是女性，强调了量身定制预防策略的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition 医学-营养学

CiteScore

14.10

自引率

6.30%

发文量

356

审稿时长

28 days

期刊介绍： Clinical Nutrition, the official journal of ESPEN, The European Society for Clinical Nutrition and Metabolism, is an international journal providing essential scientific information on nutritional and metabolic care and the relationship between nutrition and disease both in the setting of basic science and clinical practice. Published bi-monthly, each issue combines original articles and reviews providing an invaluable reference for any specialist concerned with these fields.