Prognostic value of systemic immune-inflammation index in older patients with acute coronary syndrome.

IF 1.5 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Coronary artery disease Pub Date : 2025-01-17 DOI:10.1097/MCA.0000000000001496

Ahmet Gürdal, Ebru Serin, Mert Sarilar, Mutlu Çağan Sümerkan, Erol Kalender, Hasan Değirmenci, Sinan Şahin, Kudret Keskin

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引用次数: 0

Abstract

Objectives: Contemporary studies assessing the importance of the systemic immune-inflammation index (SII) in older patients presenting with acute coronary syndrome (ACS) are scarce. This study investigated the impact and prognostic value of the SII regarding long-term mortality in older patients with ACS.

Methods: The study included 401 older patients aged 75 years and above admitted with ACS between May 2015 and December 2022. Predictors of mortality were determined using multivariate Cox regression analysis. Survival curves were generated using the Kaplan-Meier method.

Results: The patients' median age was 81 (77-85) years, and 197 (49.1%) were male. The median follow-up was 23 months (Q1-Q3 : 4-43, maximum: 102). All short- and long-term deaths, including in-hospital deaths, were significantly high in patients with high SII (P = 0.001). Inflammatory variables, including C-reactive protein, SII, the neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio, were positively correlated with the SYNTAX score (for SII; R = 0.492, P = 0.001). Multivariate Cox regression analysis revealed that age [hazard ratio (HR): 1.082, 95% confidence interval (CI): 1.051-1.114, P = 0.001], estimated glomerular filtration rate (HR: 0.988, 95% CI: 0.982-0.994, P = 0.001), SII (HR: 1.004, 95% CI: 1.001-1.006, P = 0.001), and left ventricular ejection fraction (HR: 0.959, 95% CI: 0.947-0.97, P = 0.001) were independent predictors of mortality in older patients with ACS. Kaplan-Meier analysis also showed that patients with high SII had a significantly higher mortality rate (P = 0.001).

Conclusion: A high SII is an independent predictor of long-term mortality in older patients with ACS.

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全身免疫炎症指数对老年急性冠脉综合征患者的预后价值。

目的：评估全身免疫炎症指数（SII）在老年急性冠脉综合征（ACS）患者中的重要性的当代研究很少。本研究探讨了SII对老年ACS患者长期死亡率的影响和预后价值。方法：研究纳入2015年5月至2022年12月期间收治的401例75岁及以上老年ACS患者。使用多变量Cox回归分析确定死亡率的预测因素。生存曲线采用Kaplan-Meier法生成。结果：患者中位年龄81（77 ~ 85）岁，男性197例（49.1%）。中位随访时间为23个月（Q1-Q3: 4-43，最长为102）。所有短期和长期死亡，包括院内死亡，在SII高的患者中显著高（P = 0.001）。炎症变量，包括c反应蛋白、SII、中性粒细胞与淋巴细胞比值、单核细胞与淋巴细胞比值、血小板与淋巴细胞比值，与SYNTAX评分呈正相关(SII；R = 0.492, p = 0.001)。多因素Cox回归分析显示，年龄[风险比（HR）： 1.082, 95%可信区间（CI）： 1.051 ~ 1.114, P = 0.001]、肾小球滤过率（HR: 0.988, 95% CI: 0.982 ~ 0.994, P = 0.001）、SII （HR: 1.004, 95% CI: 1.001 ~ 1.006, P = 0.001）和左室射血分数（HR: 0.959, 95% CI: 0.947 ~ 0.97, P = 0.001）是老年ACS患者死亡率的独立预测因素。Kaplan-Meier分析还显示，SII高的患者死亡率明显更高（P = 0.001）。结论：高SII是老年ACS患者长期死亡率的独立预测因子。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Coronary artery disease 医学-外周血管病

CiteScore

2.50

自引率

0.00%

发文量

190

审稿时长

6-12 weeks

期刊介绍： Coronary Artery Disease welcomes reports of original research with a clinical emphasis, including observational studies, clinical trials, translational research, novel imaging, pharmacology and interventional approaches as well as advances in laboratory research that contribute to the understanding of coronary artery disease. Each issue of Coronary Artery Disease is divided into four areas of focus: Original Research articles, Review in Depth articles by leading experts in the field, Editorials and Images in Coronary Artery Disease. The Editorials will comment on selected original research published in each issue of Coronary Artery Disease, as well as highlight controversies in coronary artery disease understanding and management. Submitted artcles undergo a preliminary review by the editor. Some articles may be returned to authors without further consideration. Those being considered for publication will undergo further assessment and peer-review by the editors and those invited to do so from a reviewer pool.