Body Composition at Diagnosis and Early Response in Pediatric Hodgkin Lymphoma.

IF 3.7 3区医学 Q2 ONCOLOGY

Cancer Epidemiology Biomarkers & Prevention Pub Date : 2025-04-03 DOI:10.1158/1055-9965.EPI-24-1231

Aman Wadhwa, Chen Dai, Sandra Kessel, Joshua S Richman, Wei Shen, Justine M Kahn, Sharon M Castellino, Kara M Kelly, Debra L Friedman, Smita Bhatia

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引用次数: 0

Abstract

Background: The association between skeletal, muscle, and adipose tissue (body composition) and early response using PET in pediatric Hodgkin lymphoma remains unstudied.

Methods: Patients enrolled on Children's Oncology Group studies AHOD0031 (intermediate-risk Hodgkin lymphoma) and AHOD0831 (high-risk Hodgkin lymphoma) with digital abdominal CT scans at diagnosis and PET scans after 2 cycles (PET2) were included. Two consecutive slices at the third lumbar vertebra were identified, and skeletal muscle index (SMI; in cm2/m2) and total adipose tissue index (TATI; in cm2/m2) were calculated using sliceOmatic and height at diagnosis. SMI and TATI were divided into quintiles [Q1 (lowest) to Q5 (highest)]. Body mass index (BMI) was calculated using height and weight at diagnosis. The association between baseline body composition (SMI, TATI, and BMI) and positive PET2 was examined using logistic regression, adjusting for age at diagnosis, sex, race/ethnicity, stage, histology, bulk disease, and "B" symptoms.

Results: Among 1,033 included patients, PET2 was positive in 314 (30.4%) patients. SMI was not associated with positive PET2. Extremes of TATI were associated with positive PET2, when compared with the middle TATI quintile [reference: Q3; ORQ1 = 1.63; 95% confidence interval (CI) = 1.03-2.60; P = 0.04; ORQ2 = 1.82; 95% CI = 1.17-2.82; P = 0.008; ORQ5 = 1.94; 95% CI = 1.23-3.05; P = 0.005]. The association between BMI in obesity range and positive PET2 trended toward significance (OR = 1.42; 95% CI = 0.98-2.04; P = 0.06; ref = normal weight).

Conclusions: Extremes of adipose tissue at diagnosis influence early response among pediatric Hodgkin lymphoma.

Impact: Validation of results from this study could inform studies investigating body composition-based chemotherapy dosing.

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儿童霍奇金淋巴瘤的身体成分诊断和早期反应。

背景：骨骼肌和脂肪组织（体成分）与儿童霍奇金淋巴瘤（HL）使用正电子发射断层扫描（PET）的早期反应之间的关系仍未研究。方法：纳入儿童肿瘤组研究AHOD0031（中危HL）和AHOD0831（高危HL）的患者，诊断时进行腹部数字计算机断层扫描（CT）， 2个周期后进行PET扫描（PET2）。确定第三腰椎连续两块切片，使用sliceOmatic （Magog, Canada）和诊断时的身高计算骨骼肌指数（SMI，单位为cm2/m2）和总脂肪组织指数（TATI，单位为cm2/m2）。SMI和TATI分为五分位数（Q1[最低]至Q5[最高]）。身体质量指数（BMI）采用诊断时的身高和体重计算。基线身体成分（SMI、TATI、BMI）与PET2阳性之间的关系使用逻辑回归进行检验，调整诊断年龄、性别、种族/民族、分期、组织学、散装疾病和‘B’症状。结果：1033例患者中，314例（30.4%）患者PET2阳性。SMI与PET2阳性无相关性。与TATI中间五分位数相比，TATI极端与PET2阳性相关(参考文献：Q3；优势比[ORQ1]=1.63, 95%可信区间[CI]=1.03 ~ 2.60， P=0.04；Orq2 =1.82, 95%ci =1.17-2.82, p =0.008；Orq5 =1.94, 95%ci =1.23-3.05, p =0.005)。肥胖范围BMI与PET2阳性呈正相关(OR=1.42, 95%CI=0.98-2.04， P=0.06；ref =正常体重)。结论：诊断时脂肪组织的极值影响儿童HL的早期反应。影响：本研究结果的验证可以为研究基于体成分的化疗剂量的研究提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Epidemiology Biomarkers & Prevention 医学-公共卫生、环境卫生与职业卫生

CiteScore

6.50

自引率

2.60%

发文量

538

审稿时长

1.6 months

期刊介绍： Cancer Epidemiology, Biomarkers & Prevention publishes original peer-reviewed, population-based research on cancer etiology, prevention, surveillance, and survivorship. The following topics are of special interest: descriptive, analytical, and molecular epidemiology; biomarkers including assay development, validation, and application; chemoprevention and other types of prevention research in the context of descriptive and observational studies; the role of behavioral factors in cancer etiology and prevention; survivorship studies; risk factors; implementation science and cancer care delivery; and the science of cancer health disparities. Besides welcoming manuscripts that address individual subjects in any of the relevant disciplines, CEBP editors encourage the submission of manuscripts with a transdisciplinary approach.