The Association Between IL-8 Gene Polymorphisms and the Risk of Several Types of Cancer, Especially in Gastric Cancer

IF 1.5 Q4 ONCOLOGY

Cancer reports Pub Date : 2025-01-17 DOI:10.1002/cnr2.70103

Bin Xu, Yidan Yan

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Abstract

Background

Changes in functional genetic polymorphisms may increase or decrease the risk of cancer in patients. Nowadays, the association between polymorphisms in the interleukin-8 (IL-8) gene and the susceptibility of cancer risk have been investigated in many studies, however, above relationships remain unclear.

Aim

The current study aims to comprehensively evaluate the association between IL-8 gene six polymorphisms and the whole cancer risk, especially −251 polymorphism and gastric cancer.

Methods and Results

Six polymorphisms (−251, −353, +678, +1633, +2767, +781) were collected. The expression of serum IL-8 was calculated by ELISA assay. First, 104 case–control studies were conducted. Second, this research has made significant discoveries regarding the −251, −353 and +781 polymorphisms and the potential associations with cancer risk. Finally, the serum IL-8 levels in gastric cancer patients with AA/TT genotypes were significantly higher than those with the same genotypes of healthy controls and TT genotypes in gastric cancer patients.

Conclusion

Overall, the investigation has revealed that IL-8 gene polymorphisms significantly influence vulnerability to cancer development, especially for gastric cancer.

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IL-8基因多态性与几种癌症，特别是胃癌风险的关系

背景：功能性基因多态性的改变可能增加或降低患者患癌症的风险。目前，许多研究已经探讨了白细胞介素-8 （IL-8）基因多态性与癌症易感性之间的关系，但上述关系尚不清楚。目的：本研究旨在综合评价IL-8基因6多态性与整体癌症风险的关系，特别是-251多态性与胃癌的关系。方法与结果：收集到6个多态性（-251,-353,+678,+1633,+2767,+781）。ELISA法测定血清IL-8的表达。首先，进行了104项病例对照研究。其次，本研究在-251、-353和+781多态性及其与癌症风险的潜在关联方面取得了重大发现。最后，AA/TT基因型胃癌患者血清IL-8水平显著高于相同基因型的健康对照和TT基因型胃癌患者。结论：总体而言，研究表明IL-8基因多态性显著影响肿瘤易感性，尤其是胃癌易感性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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