Ionic Liquid Aided [¹¹C]CO Fixation for Synthesis of ¹¹C-carbonyls.

IF 2.5 4区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

ChemistryOpen Pub Date : 2025-01-20 DOI:10.1002/open.202400410

Anton Lindberg, Narges Mokhatarinori, Zhenzhen Yang, Sheng Dai, Ilja Popovs, Neil Vasdev

引用次数: 0

Abstract

Tributyl(ethyl)phosphonium oxopentenolate ([P₄₄₄₂][Pen]) is an ionic liquid developed to capture CO and has shown ability to catalyze carbonylation reactions in organic chemistry. Carbon-11 (¹¹C, t_1/2=20.4 min) labeled CO is a highly versatile building block for the synthesis of positron emission tomography (PET) radiotracers that are applied for medical imaging. The use of [¹¹C]CO is limited by its low solubility in organic solvents. Herein, we report a proof-of-concept study evaluating a new method to prepare ¹¹C-labeled amides, ureas and carbamates via reaction of [¹¹C]CO in [P₄₄₄₂][Pen] and applied for fully automated radiosyntheses of Bruton's tyrosine kinase inhibitors, [¹¹C]evobrutinib and [¹¹C]ibrutinib.

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离子液体辅助[11C]CO固定合成11C-羰基。

三丁基（乙基）磷氧戊烯酸酯（[P4442][Pen]）是一种用于捕获CO的离子液体，在有机化学中具有催化羰基化反应的能力。碳-11 （11C, t1/2=20.4 min）标记的CO是合成用于医学成像的正电子发射断层扫描（PET）放射性示踪剂的高度通用的构建块。[11C]CO在有机溶剂中的溶解度低，限制了它的使用。在此，我们报告了一项概念验证研究，评估了一种通过[11C]CO在[P4442][Pen]中的反应制备11C标记的酰胺、尿素和氨基甲酸酯的新方法，并应用于布鲁顿酪氨酸激酶抑制剂[11C]evobrutinib和[11C]ibrutinib的全自动放射性合成。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemistryOpen CHEMISTRY, MULTIDISCIPLINARY-

CiteScore

4.80

自引率

4.30%

发文量

143

审稿时长

1 months

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Ionic Liquid Aided [11C]CO Fixation for Synthesis of 11C-carbonyls.

Abstract

Ionic Liquid Aided [¹¹C]CO Fixation for Synthesis of ¹¹C-carbonyls.