Circular RNAs in the management of human osteoporosis.

IF 6.7 2区医学 Q1 Medicine

British medical bulletin Pub Date : 2025-01-16 DOI:10.1093/bmb/ldae024

Giuseppe Gargano, Simona M Pagano, Nicola Maffulli

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引用次数: 0

Abstract

Background: Osteoporosis (OP) is a metabolic bone disease producing reduction in bone mass with consequent bone fragility. Circular ribonucleic acid (CircRNA) is a form of RNA that forms a loop structure rather than a linear one. CircRNA can be used for therapeutic purposes, including molecular targets or to test new therapies.

Sources of data: A systematic search of different databases to July 2024 was performed to define the role of circRNA in OP therapy. Seventeen suitable studies were identified.

Areas of agreement: CircRNAs may be useful in studying metabolic processes in OP and identify possible therapeutic targets and new drug therapies.

Areas of controversy: The metabolic processes involved in OP are regulated by many genes and cytokines that can be targeted by CircRNAs. However, it is not easy to predict whether the in vitro responses of the studied CircRNAs and their interaction with drugs are also applicable in vivo.

Growing points: Metabolic processes can be affected by gene dysregulation of CircRNAs on various growth factors. Areas timely for developing research: Despite the predictability of CircRNA pharmacological response in vitro, such pharmacological response cannot be expected to be replicated in vivo.

Data availability: The data that support the findings of this study are available from the corresponding author.

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环状rna在人类骨质疏松症治疗中的应用。

背景：骨质疏松症（OP）是一种代谢性骨病，导致骨量减少，从而导致骨脆性。环状核糖核酸（CircRNA）是一种形成环状结构而不是线性结构的RNA。CircRNA可用于治疗目的，包括分子靶点或测试新疗法。数据来源：对截至2024年7月的不同数据库进行了系统搜索，以确定circRNA在OP治疗中的作用。确定了17项合适的研究。共识领域：CircRNAs可能有助于研究OP的代谢过程，并确定可能的治疗靶点和新的药物疗法。争议领域：OP中涉及的代谢过程受到许多基因和细胞因子的调节，这些基因和细胞因子可以被CircRNAs靶向。然而，所研究的circrna的体外反应及其与药物的相互作用是否也适用于体内，尚不容易预测。生长点：各种生长因子上的circrna基因失调会影响代谢过程。及时开展研究的领域：尽管CircRNA在体外的药理反应是可预测的，但这种药理反应不能期望在体内被复制。数据可得性：支持本研究结果的数据可从通讯作者处获得。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

British medical bulletin 医学-医学：内科

CiteScore

13.10

自引率

1.50%

发文量

审稿时长

>12 weeks

期刊介绍： British Medical Bulletin is a multidisciplinary publication, which comprises high quality reviews aimed at generalist physicians, junior doctors, and medical students in both developed and developing countries. Its key aims are to provide interpretations of growing points in medicine by trusted experts in the field, and to assist practitioners in incorporating not just evidence but new conceptual ways of thinking into their practice.