Yongna Yao, Kui Deng, Jun Zhu, Qi Li, Liangcheng Xiang, Xuelian Yuan, Yanping Wang, Zheng Liu, Huiwen Tan, Xiaohong Li
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引用次数: 0
Abstract
Background: Seasonality in the incidence of congenital hypothyroidism (CH) has been identified in several countries and different conclusions have been drawn. The objective of this study was to examine whether this seasonality is also observable in China and how it manifests across different temperate zones.
Methods: Data on CH cases and screened neonates between January 1, 2014, and September 30, 2022, by year and season, were sourced from the Chinese Newborn Screening Information System. The overall CH incidence and incidence across different temperate zones was analyzed by using the seasonal unit root test, seasonal decomposition, and deterministic seasonal means regression model.
Results: A total of 29,259 CH cases were reported nationwide from season one of 2014 to season three of 2022. Quarterly CH incidence showed an upward time trend and significant seasonality among all zones, but with different patterns. Overall, season one was the peak period with an incidence rate of 7.09 per 10,000 neonates, whilst season two was the trough period with an incidence rate of 5.89. Subtropical, warm, and medium temperate zones had one peak period in season one, whilst the tropical zone had two peak periods in seasons one and three. In comparison, the plateau zone had a trough season in season one.
Conclusion: Our study found the quarterly CH incidence exhibited clear seasonality, temperate zone-specific patterns, and an upward time trend in China. This finding is particularly concerning given China's decline in the number of births, underscoring the urgency of allocating resources appropriately in screening programs.
期刊介绍：
The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks.
Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.
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