Acute zonal occult outer retinopathy (AZOOR) complex associated with torpedo retinopathy following COVID-19 recombinant mRNA vaccination: a case report of a rare clinical presentation.

IF 1.7 4区医学 Q3 OPHTHALMOLOGY

BMC Ophthalmology Pub Date : 2025-01-17 DOI:10.1186/s12886-025-03844-z

Nai-Wen Chang, Chia-Hao Kuo, Hung-Da Chou, Yi-Hsing Chen

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引用次数: 0

Abstract

Background: While vaccination remains crucial in mitigating the impact of the COVID-19 pandemic, several ocular adverse events has been reported, including Acute Zonal Occult Outer Retinopathy (AZOOR) complex.

Case presentation: A 31-year-old female presented declined best corrected visual acuity (BCVA) and flashes in both eyes three days following second recombinant mRNA COVID-19 vaccine (Moderna). Fundus autofluorescence (FAF) illustrated speckled hyper-AF lesions surrounding right eye torpedo maculopathy site and hyper-AF lesions in the left macula. The spectral-domain optical coherence tomography delineated inner and outer segment (IS/OS) line disruption; hyperreflective deposits in the outer nuclear layer (ONL); and undetectable interdigitation zone (IDZ). Her BCVA further declined after 3-month observation, thus she received 8-month oral prednisolone and mycophenolate mofetil treatment. Her BCVA recovered; the hype-AF lesions resolved; and the IS/OS line and ONL resumed.

Conclusions: We present a rare case of AZOOR complex following COVID-19 vaccination inciting from torpedo retinopathy where outer-retinal barrier breaks down.

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COVID-19重组mRNA疫苗接种后与鱼雷视网膜病变相关的急性区域性隐匿性外视网膜病变（AZOOR）复合物：罕见临床表现的病例报告

背景：虽然疫苗接种对于减轻COVID-19大流行的影响仍然至关重要，但已报道了一些眼部不良事件，包括急性区域性隐匿性外视网膜病变（AZOOR）复合物。病例介绍：一名31岁女性，在第二次重组mRNA COVID-19疫苗（Moderna）接种后3天出现最佳矫正视力（BCVA）下降和双眼闪光。眼底自身荧光（FAF）显示右眼鱼雷黄斑病变周围有斑点状高af病变，左侧黄斑有高af病变。光谱域光学相干层析成像圈定内外段（IS/OS）线中断；外核层超反射沉积（ONL）；和不可探测的指间带（IDZ）。观察3个月后BCVA进一步下降，给予8个月口服强的松龙加霉酚酸酯治疗。患者BCVA恢复；hypelaf病变消退；IS/OS线路和ONL恢复。结论：我们报告了一例罕见的由视网膜外屏障破坏的鱼雷视网膜病变引起的COVID-19疫苗接种后AZOOR复合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

BMC Ophthalmology OPHTHALMOLOGY-

CiteScore

3.40

自引率

5.00%

发文量

441

审稿时长

6-12 weeks

期刊介绍： BMC Ophthalmology is an open access, peer-reviewed journal that considers articles on all aspects of the prevention, diagnosis and management of eye disorders, as well as related molecular genetics, pathophysiology, and epidemiology.