Monte Carlo-based realistic simulation of optical coherence tomography angiography.

IF 2.9 2区 医学 Q2 BIOCHEMICAL RESEARCH METHODS
Biomedical optics express Pub Date : 2024-12-11 eCollection Date: 2025-01-01 DOI:10.1364/BOE.540916
Jianing Mao, Hang Su, Ping Xue, Yuye Ling
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引用次数: 0

Abstract

Optical coherence tomography angiography (OCTA) offers unparalleled capabilities for non-invasive detection of vessels. However, the lack of accurate models for light-tissue interaction in OCTA jeopardizes the development of the techniques to further extract quantitative information from the measurements. In this manuscript, we propose a Monte Carlo (MC)-based simulation method to precisely describe the signal formation of OCTA based on the fundamental theory of light-tissue interactions. A dynamic particle-fixed model is developed to depict the spatial-temporal behaviors of the tissue phantom: the particles are initialized and fixed in specific locations with wavelength-dependent scattering cross-sections and are allowed to travel over time. We then employ a full-spectrum MC engine to faithfully simulate the formation of OCT and OCTA images. A simulation on a vessel-mimicking phantom demonstrated that speckle characteristics in OCT as well as decorrelation maps in OCTA could be successfully reproduced. We further illustrate the usefulness of our method on the quantitative OCTA by extending it to simulate the gradual saturation of decorrelation in OCTA-based velocimetry. We believe our method will serve as a valuable tool for studying OCTA theory and inspire better solutions and metrics for non-invasive flow velocity measurement.

基于蒙特卡罗的光学相干断层血管造影的现实模拟。
光学相干断层扫描血管造影(OCTA)提供了无与伦比的能力,非侵入性检测血管。然而,OCTA中光组织相互作用的精确模型的缺乏危及了进一步从测量中提取定量信息的技术的发展。本文基于光组织相互作用的基本理论,提出了一种基于蒙特卡罗(Monte Carlo, MC)的模拟方法来精确描述OCTA的信号形成。开发了一个动态粒子固定模型来描述组织幻影的时空行为:粒子被初始化并固定在具有波长相关散射截面的特定位置,并允许随时间移动。然后,我们使用全谱MC引擎来忠实地模拟OCT和OCTA图像的形成。在血管模拟模型上的模拟表明,OCT中的散斑特征以及OCTA中的去相关图可以成功地再现。我们进一步说明了我们的方法在定量OCTA上的实用性,通过扩展它来模拟基于OCTA的速度测量中去相关的逐渐饱和。我们相信我们的方法将成为研究OCTA理论的有价值的工具,并为非侵入性流速测量提供更好的解决方案和指标。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biomedical optics express
Biomedical optics express BIOCHEMICAL RESEARCH METHODS-OPTICS
CiteScore
6.80
自引率
11.80%
发文量
633
审稿时长
1 months
期刊介绍: The journal''s scope encompasses fundamental research, technology development, biomedical studies and clinical applications. BOEx focuses on the leading edge topics in the field, including: Tissue optics and spectroscopy Novel microscopies Optical coherence tomography Diffuse and fluorescence tomography Photoacoustic and multimodal imaging Molecular imaging and therapies Nanophotonic biosensing Optical biophysics/photobiology Microfluidic optical devices Vision research.
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