Endometriosis and autoimmunity

IF 9.2 1区医学 Q1 IMMUNOLOGY

Autoimmunity reviews Pub Date : 2025-01-17 DOI:10.1016/j.autrev.2025.103752

Luz P. Blanco , Noemi Salmeri , Sarah M. Temkin , Victoria K. Shanmugam , Pamela Stratton

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Abstract

Endometriosis is a female-specific chronic condition that affects 1 in 10 women and other individuals with a uterus worldwide with common symptoms that include pelvic pain and infertility. Reliable and effective non-invasive biomarkers for endometriosis do not exist, and therefore currently a diagnosis of endometriosis requires direct visualization of lesions at surgery. Similarly, few safe and effective management strategies exist for endometriosis, with hormonal interventions and surgery only providing temporary symptom control. The development of endometriosis involves the implantation and proliferation of ectopic endometrial cells which triggers local and systemic inflammation and fibrosis. While multiple genetic, environmental, and lifestyle factors appear to influence the natural history of endometriosis, chronic inflammation is a hallmark feature associated with development and progression of the disease. Data further shows that endometriosis commonly co-occurs with autoimmune diseases, adding evidence that immune dysfunction likely contributes to the pathogenesis of this disorder. Specific innate and adaptive immune system drivers of endometriosis remain to be identified and additional research is needed to elucidate the mechanistic underpinnings of this debilitating disease. In this narrative review, we discuss the shared biological mechanisms and plausible immune-related connections between endometriosis and autoimmunity.

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子宫内膜异位症与自身免疫。

子宫内膜异位症是一种女性特有的慢性疾病，全世界有十分之一的女性和其他有子宫的人受到影响，常见症状包括盆腔疼痛和不孕。子宫内膜异位症的可靠和有效的非侵入性生物标志物尚不存在，因此目前子宫内膜异位症的诊断需要在手术中直接观察病变。同样，对于子宫内膜异位症也没有安全有效的治疗策略，激素干预和手术只能暂时控制症状。子宫内膜异位症的发展涉及异位子宫内膜细胞的植入和增殖，引发局部和全身炎症和纤维化。虽然多种遗传、环境和生活方式因素似乎影响子宫内膜异位症的自然史，但慢性炎症是与该疾病的发生和进展相关的一个标志性特征。数据进一步表明，子宫内膜异位症通常与自身免疫性疾病共同发生，增加了免疫功能障碍可能导致这种疾病发病的证据。子宫内膜异位症的特异性先天和适应性免疫系统驱动因素仍有待确定，需要进一步的研究来阐明这种使人衰弱的疾病的机制基础。在这篇叙述性综述中，我们讨论了子宫内膜异位症和自身免疫之间的共同生物学机制和可能的免疫相关联系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Autoimmunity reviews 医学-免疫学

CiteScore

24.70

自引率

4.40%

发文量

164

审稿时长

21 days

期刊介绍： Autoimmunity Reviews is a publication that features up-to-date, structured reviews on various topics in the field of autoimmunity. These reviews are written by renowned experts and include demonstrative illustrations and tables. Each article will have a clear "take-home" message for readers. The selection of articles is primarily done by the Editors-in-Chief, based on recommendations from the international Editorial Board. The topics covered in the articles span all areas of autoimmunology, aiming to bridge the gap between basic and clinical sciences. In terms of content, the contributions in basic sciences delve into the pathophysiology and mechanisms of autoimmune disorders, as well as genomics and proteomics. On the other hand, clinical contributions focus on diseases related to autoimmunity, novel therapies, and clinical associations. Autoimmunity Reviews is internationally recognized, and its articles are indexed and abstracted in prestigious databases such as PubMed/Medline, Science Citation Index Expanded, Biosciences Information Services, and Chemical Abstracts.