Thandiwe Msipu Phiri, Tadatsugu Imamura, Peter Chibale Mwansa, Ilunga Mathews, Frazer Mtine, Jedidiah Chanda, Mulenga Salasini, Takanori Funaki, Kapona Otridah, Kunda Musonda, Roma Chilengi
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引用次数: 0
Abstract
Zambia experienced the largest cholera epidemic in the country's history in 2023-2024; however, the antimicrobial susceptibility profile of Vibrio cholerae during the epidemic is unknown. A total of 2,384 stool samples were collected from suspected cholera cases in Eastern, Lusaka, and Luapula provinces in Zambia from January 2023 to March 2024. Among them, 549 (23.5%, n = 549 of 2,341) were culture positive for V. cholerae O1, and antimicrobial susceptibility results were available for 431 (78.5%, n = 431 of 549). Sensitivity for tetracycline was 84.5% (n = 316 of 374) in Lusaka, whereas it was 100% in Eastern and Luapula provinces. Isolates resistant to azithromycin were found only in Lusaka (1.6%, n = 1 of 61). Sensitivity for ciprofloxacin was 81.8% (n = 260 of 318) in Lusaka province, whereas it was 100% in other provinces. Our results suggested an increased prevalence of antimicrobial resistance in V. cholerae against the first- and second-line antibiotic treatments, particularly in the capital. Careful monitoring of the regional antibiogram is warranted.
期刊介绍：
The American Journal of Tropical Medicine and Hygiene, established in 1921, is published monthly by the American Society of Tropical Medicine and Hygiene. It is among the top-ranked tropical medicine journals in the world publishing original scientific articles and the latest science covering new research with an emphasis on population, clinical and laboratory science and the application of technology in the fields of tropical medicine, parasitology, immunology, infectious diseases, epidemiology, basic and molecular biology, virology and international medicine.
The Journal publishes unsolicited peer-reviewed manuscripts, review articles, short reports, images in Clinical Tropical Medicine, case studies, reports on the efficacy of new drugs and methods of treatment, prevention and control methodologies,new testing methods and equipment, book reports and Letters to the Editor. Topics range from applied epidemiology in such relevant areas as AIDS to the molecular biology of vaccine development.
The Journal is of interest to epidemiologists, parasitologists, virologists, clinicians, entomologists and public health officials who are concerned with health issues of the tropics, developing nations and emerging infectious diseases. Major granting institutions including philanthropic and governmental institutions active in the public health field, and medical and scientific libraries throughout the world purchase the Journal.
Two or more supplements to the Journal on topics of special interest are published annually. These supplements represent comprehensive and multidisciplinary discussions of issues of concern to tropical disease specialists and health issues of developing countries
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