A systematic review and network meta-analysis of RCTs: The effect of systemic immunotherapies on treatment outcomes and quality of life in patients with metastatic colorectal cancer.

IF 2.1 4区 医学 Q3 MEDICINE, RESEARCH & EXPERIMENTAL
Yiying Zhu, Xiangwei Fu, Yonggang Dai
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引用次数: 0

Abstract

Background: The impact of different systemic treatments on the health-related quality of life (HRQoL) in patients with metastatic colorectal cancer (mCRC) is still unclear.

Objectives: To compare and evaluate the effects of various systemic interventions on the HRQoL in patients with mCRC.

Material and methods: A thorough search was conducted using four electronic databases (PubMed, Embase, Scopus, and Cochrane Library) to locate relevant literature published in peer-reviewed journals. The risk ratio (RR) and 95% confidence intervals (95% CIs) were calculated. The heterogeneity was examined using p-value, Cochrane Q and I² statistics. The analysis was performed with RevMan 5.4. At least 2 treatment regimens were tested in phase II or III trials. The primary objectives were shortand long-term mean changes in EORTC QLQ-C30 GHS/QoL (European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire - Core 30, Global Health Status/Quality of Life) and EQ-5D health utility scores (EuroQol 5 Dimension). Multivariate meta-regression was used to combine direct and indirect comparison data into a network meta-analysis with a random-effects consistency model. The surface under the cumulative ranking (SUCRA) probability curve was used to compare different systemic therapy combinations.

Results: This meta-analysis involved 15 relevant randomized clinical trials (RCTs) with 7,699 patients with mCRC. The study had a low risk of bias (RoB) (p > 0.05 for Egger's regression test) and moderate heterogeneity (I2 < 60%). Results indicated that systemic therapies were substantially more effective than other agents in improving the overall survival (OS) of patients (RR: 0.85 (95% CI: 0.79-0.90); p < 0.001, I2 < 60%], ensuring progression-free survival (PFS) (RR 0.80 (95% CI: 0.75-0.85); p < 0.001; I2 < 60%), suggesting that there was moderate heterogeneity. Long-term findings demonstrated that cetuximab was the most effective treatment and was linked to a significant improvement in GHS/QoL.(coefficient [95% CI] = 0.23 [-0.68 to 0.96], p = 0.747). In terms of the longand short-term results of change in QLQ-C30 GHS/HUS QoL score, cetuximab performed the best (SUCRA 95.12%) among all therapies. It also showed a substantial advantage in comparison to chemotherapy (mean deviation (MD) 0.06, 95% CI: 0.01 to 0.09).

Conclusion: This network meta-analysis found that cetuximab monotherapy improves HRQoL and prolongs OS and PFS in patients with mCRC.

随机对照试验的系统回顾和网络荟萃分析:全身免疫疗法对转移性结直肠癌患者治疗结果和生活质量的影响。
背景:不同的全身治疗对转移性结直肠癌(mCRC)患者健康相关生活质量(HRQoL)的影响尚不清楚。目的:比较和评价各种系统干预措施对mCRC患者HRQoL的影响。材料和方法:使用PubMed、Embase、Scopus和Cochrane Library四个电子数据库进行全面检索,找到同行评议期刊上发表的相关文献。计算风险比(RR)和95%置信区间(95% ci)。采用p值、Cochrane Q和I²统计量检验异质性。使用RevMan 5.4软件进行分析。至少有两种治疗方案在II期或III期试验中进行了测试。主要目标是EORTC QLQ-C30 GHS/QoL(欧洲癌症研究和治疗组织生活质量问卷-核心30,全球健康状况/生活质量)和EQ-5D健康效用评分(EuroQol 5维度)的短期和长期平均变化。采用多元元回归方法,将直接和间接比较数据合并为具有随机效应一致性模型的网络元分析。采用累积排序(SUCRA)概率曲线下曲面比较不同的全身治疗组合。结果:本荟萃分析纳入了15项相关的随机临床试验(RCTs),涉及7699例mCRC患者。本研究具有低偏倚风险(RoB) (Egger回归检验p < 0.05)和中等异质性(I2 < 60%)。结果表明,在改善患者的总生存期(OS)方面,全身治疗明显比其他药物更有效(RR: 0.85 (95% CI: 0.79-0.90);p < 0.001, I2 < 60%],确保无进展生存期(PFS) (RR 0.80 (95% CI: 0.75-0.85);P < 0.001;I2 < 60%),表明存在中等异质性。长期研究结果表明,西妥昔单抗是最有效的治疗方法,与GHS/QoL的显著改善有关。(系数[95% CI] = 0.23 [-0.68 ~ 0.96], p = 0.747)。从QLQ-C30 GHS/HUS QoL评分变化的长短期结果来看,西妥昔单抗在所有治疗中表现最好(SUCRA为95.12%)。与化疗相比,它也显示出实质性的优势(平均偏差(MD) 0.06, 95% CI: 0.01至0.09)。结论:该网络荟萃分析发现,西妥昔单抗单药治疗可改善mCRC患者的HRQoL,延长OS和PFS。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Advances in Clinical and Experimental Medicine
Advances in Clinical and Experimental Medicine MEDICINE, RESEARCH & EXPERIMENTAL-
CiteScore
3.70
自引率
4.80%
发文量
153
审稿时长
6-12 weeks
期刊介绍: Advances in Clinical and Experimental Medicine has been published by the Wroclaw Medical University since 1992. Establishing the medical journal was the idea of Prof. Bogumił Halawa, Chair of the Department of Cardiology, and was fully supported by the Rector of Wroclaw Medical University, Prof. Zbigniew Knapik. Prof. Halawa was also the first editor-in-chief, between 1992-1997. The journal, then entitled "Postępy Medycyny Klinicznej i Doświadczalnej", appeared quarterly. Prof. Leszek Paradowski was editor-in-chief from 1997-1999. In 1998 he initiated alterations in the profile and cover design of the journal which were accepted by the Editorial Board. The title was changed to Advances in Clinical and Experimental Medicine. Articles in English were welcomed. A number of outstanding representatives of medical science from Poland and abroad were invited to participate in the newly established International Editorial Staff. Prof. Antonina Harłozińska-Szmyrka was editor-in-chief in years 2000-2005, in years 2006-2007 once again prof. Leszek Paradowski and prof. Maria Podolak-Dawidziak was editor-in-chief in years 2008-2016. Since 2017 the editor-in chief is prof. Maciej Bagłaj. Since July 2005, original papers have been published only in English. Case reports are no longer accepted. The manuscripts are reviewed by two independent reviewers and a statistical reviewer, and English texts are proofread by a native speaker. The journal has been indexed in several databases: Scopus, Ulrich’sTM International Periodicals Directory, Index Copernicus and since 2007 in Thomson Reuters databases: Science Citation Index Expanded i Journal Citation Reports/Science Edition. In 2010 the journal obtained Impact Factor which is now 1.179 pts. Articles published in the journal are worth 15 points among Polish journals according to the Polish Committee for Scientific Research and 169.43 points according to the Index Copernicus. Since November 7, 2012, Advances in Clinical and Experimental Medicine has been indexed and included in National Library of Medicine’s MEDLINE database. English abstracts printed in the journal are included and searchable using PubMed http://www.ncbi.nlm.nih.gov/pubmed.
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