Hunting glioblastoma recurrence: glioma stem cells as retrospective targets.

IF 5 2区生物学 Q2 CELL BIOLOGY

American journal of physiology. Cell physiology Pub Date : 2025-03-01 Epub Date: 2025-01-16 DOI:10.1152/ajpcell.00344.2024

Sümeyra Mengüç Emir, Birnur Sinem Karaoğlan, Ramazan Kaşmer, Hilal Buse Şirin, Batuhan Sarıyıldız, Nihal Karakaş

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引用次数: 0

Abstract

Glioblastoma (GBM) remains one of the most aggressive and treatment-resistant brain malignancies in adults. Standard approaches, including surgical resection followed by adjuvant radio- and chemotherapy with temozolomide (TMZ), provide only transient control, as GBM frequently recurs due to its infiltrative nature and the presence of therapy-resistant subpopulations such as glioma stem cells (GSCs). GSCs, with their quiescent state and robust resistance mechanisms, evade conventional therapies, contributing significantly to relapse. Consequently, current treatment methods for GBM face significant limitations in effectively targeting GSCs. In this review, we emphasize the relationship between GBM recurrence and GSCs, discuss the current limitations, and provide future perspectives to overwhelm the challenges associated with targeting GSCs. Eliminating GSCs may suppress recurrence, achieve durable responses, and improve therapeutic outcomes for patients with GBM.

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寻找胶质瘤复发：胶质瘤干细胞作为回顾性目标。

胶质母细胞瘤（GBM）仍然是成人中最具侵袭性和治疗抗性的脑恶性肿瘤之一。标准方法，包括手术切除后辅以替莫唑胺放疗和化疗，只能提供短暂的控制，因为GBM由于其浸润性和治疗耐药亚群（如胶质瘤干细胞）的存在而经常复发。GSCs具有静止状态和强大的耐药机制，逃避常规治疗，显著促进复发。因此，目前针对GBM的治疗方法在有效靶向GSCs方面面临显著的局限性。在这篇综述中，我们强调了GBM复发与GSCs的关系，讨论了目前的局限性；并提供未来的观点，以克服与靶向GSCs相关的挑战。消除GSCs可以抑制复发，实现持久的反应，并改善GBM患者的治疗结果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American journal of physiology. Cell physiology 生物-生理学

CiteScore

9.10

自引率

1.80%

发文量

252

审稿时长

1 months

期刊介绍： The American Journal of Physiology-Cell Physiology is dedicated to innovative approaches to the study of cell and molecular physiology. Contributions that use cellular and molecular approaches to shed light on mechanisms of physiological control at higher levels of organization also appear regularly. Manuscripts dealing with the structure and function of cell membranes, contractile systems, cellular organelles, and membrane channels, transporters, and pumps are encouraged. Studies dealing with integrated regulation of cellular function, including mechanisms of signal transduction, development, gene expression, cell-to-cell interactions, and the cell physiology of pathophysiological states, are also eagerly sought. Interdisciplinary studies that apply the approaches of biochemistry, biophysics, molecular biology, morphology, and immunology to the determination of new principles in cell physiology are especially welcome.