Epidemiology and survival analysis according to the histologic subtype of pancreatic cancer: a population-based cohort study.

IF 1.2 4区医学 Q3 SURGERY

Annals of Surgical Treatment and Research Pub Date : 2025-01-01 Epub Date: 2025-01-07 DOI:10.4174/astr.2025.108.1.20

Hyeong Min Park, Mee Joo Kang, Sang-Jae Park, Kyu-Won Jung, Sung-Sik Han

{"title":"Epidemiology and survival analysis according to the histologic subtype of pancreatic cancer: a population-based cohort study.","authors":"Hyeong Min Park, Mee Joo Kang, Sang-Jae Park, Kyu-Won Jung, Sung-Sik Han","doi":"10.4174/astr.2025.108.1.20","DOIUrl":null,"url":null,"abstract":"Purpose: This study investigated epidemiologic features of patients with pancreatic cancer in Korea, according to the histologic subtypes.Methods: The Korea Central Cancer Registry data on patients with pancreatic cancer from 1999 to 2019 were reviewed. The 101,446 patients with pancreatic cancer (C25 based on the International Classification of Diseases, 10th revision) were allocated according to the following morphological codes: A, endocrine; B, carcinoma excluding cystic and mucinous; C, cystic or mucinous; D, acinar cell; and E, sarcoma and soft tissue tumor.Results: The distribution of each pancreatic cancer subtype group in Korea from 1999 to 2019 was as follows: A, n = 3,101 (3.1%); B, n = 95,051 (93.7%); C, n = 2,856 (2.8%); D, n = 299 (0.3%); and E, n = 139 (0.1%). In group B, 49.2% of patients were aged >70 years, and half of them did not receive treatment within 4 months of diagnosis. In addition, only 30.9% of the patients were in the localized and regional stage in which surgical treatment was possible. Pancreatic cancer occurred more frequently in females than in males only in group C. Between 1999 and 2019, the average annual percentage changes in the age-specific incidence rates were positive in groups A (13.9%, P < 0.001), B (1.0%, P < 0.001), and C (6.5%, P = 0.025). Significant improvements in 5-year survival rates over time were observed in subtypes A, B, and C.Conclusion: The subgroups of pancreatic cancer show different epidemiologic features, including incidences, treatment rates, and prognoses.","PeriodicalId":8071,"journal":{"name":"Annals of Surgical Treatment and Research","volume":"108 1","pages":"20-30"},"PeriodicalIF":1.2000,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11735170/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Annals of Surgical Treatment and Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.4174/astr.2025.108.1.20","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/7 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: This study investigated epidemiologic features of patients with pancreatic cancer in Korea, according to the histologic subtypes.

Methods: The Korea Central Cancer Registry data on patients with pancreatic cancer from 1999 to 2019 were reviewed. The 101,446 patients with pancreatic cancer (C25 based on the International Classification of Diseases, 10th revision) were allocated according to the following morphological codes: A, endocrine; B, carcinoma excluding cystic and mucinous; C, cystic or mucinous; D, acinar cell; and E, sarcoma and soft tissue tumor.

Results: The distribution of each pancreatic cancer subtype group in Korea from 1999 to 2019 was as follows: A, n = 3,101 (3.1%); B, n = 95,051 (93.7%); C, n = 2,856 (2.8%); D, n = 299 (0.3%); and E, n = 139 (0.1%). In group B, 49.2% of patients were aged >70 years, and half of them did not receive treatment within 4 months of diagnosis. In addition, only 30.9% of the patients were in the localized and regional stage in which surgical treatment was possible. Pancreatic cancer occurred more frequently in females than in males only in group C. Between 1999 and 2019, the average annual percentage changes in the age-specific incidence rates were positive in groups A (13.9%, P < 0.001), B (1.0%, P < 0.001), and C (6.5%, P = 0.025). Significant improvements in 5-year survival rates over time were observed in subtypes A, B, and C.

Conclusion: The subgroups of pancreatic cancer show different epidemiologic features, including incidences, treatment rates, and prognoses.

查看原文本刊更多论文

胰腺癌组织学亚型的流行病学和生存分析：一项基于人群的队列研究。

目的：本研究调查韩国胰腺癌患者的流行病学特征，根据组织学亚型。方法：回顾韩国中央癌症登记处1999年至2019年胰腺癌患者的数据。101446例胰腺癌患者（根据《国际疾病分类》第十版C25）按以下形态学编码进行分配：A，内分泌；B，癌不包括囊性和黏液性；C，囊性或粘液性；D，腺泡细胞；E为肉瘤和软组织肿瘤。结果：1999 - 2019年韩国胰腺癌各亚型组分布情况如下：A， n = 3101例（3.1%）；B, n = 95,051 (93.7%)；C, n = 2,856 (2.8%)；D, n = 299 (0.3%)；E, n = 139（0.1%）。B组49.2%的患者年龄在50 ~ 70岁之间，其中一半患者在诊断后4个月内未接受治疗。此外，只有30.9%的患者处于局部和局部阶段，可以进行手术治疗。在1999年至2019年期间，A组（13.9%,P < 0.001）、B组（1.0%,P < 0.001）和C组（6.5%,P = 0.025）的年龄特异性发病率的平均年变化百分比均为阳性。随着时间的推移，观察到A、B和c亚型的5年生存率显著改善。结论：胰腺癌亚组具有不同的流行病学特征，包括发病率、治疗率和预后。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Annals of Surgical Treatment and Research SURGERY-

CiteScore

2.30

自引率

7.10%

发文量

期刊介绍： Manuscripts to the Annals of Surgical Treatment and Research (Ann Surg Treat Res) should be written in English according to the instructions for authors. If the details are not described below, the style should follow the Uniform Requirements for Manuscripts Submitted to Biomedical Journals: Writing and Editing for Biomedical Publications available at International Committee of Medical Journal Editors (ICMJE) website (http://www.icmje.org).