Newly defined biomarker for the no reflow phenomenon in patients with non-ST elevation acute coronary syndrome; uric acid to creatinine ratio.

IF 2.1 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Acta cardiologica Pub Date : 2025-02-01 Epub Date: 2025-01-16 DOI:10.1080/00015385.2025.2452101

Muhsin Kalyoncuoglu, Ayca Gumusdag, Huseyin Oguz, Hasan Ogur, Semi Ozturk, Dilay Karabulut

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引用次数: 0

Abstract

Background: The present study aimed to investigate whether newly defined serum uric acid (SUA) to serum creatinine ratio (SUA/SCr) predicts no-reflow phenomenon (NRP) development in patients with non-ST-elevated acute coronary syndrome (NSTE-ACS).

Methods: The study group was divided into two groups: those who developed NRP and those who did not. Complete blood counts, SUA, serum creatinine, C-reactive protein (CRP) and albumin were obtained at admission. The SUA/SCr, SUA to albumin ratio (UAR), C-reactive protein to albumin ratio (CAR) and systemic immune inflammation (SII) index values of all patients were calculated and their relationships with NRP were evaluated.

Results: Patients with NRP had higher mean SUA/SCr ratio (7.19 ± 2.14 vs 5.30 ± 1.70, p < 0.001), mean UAR (1.73 ± 0.69 vs 1.38 ± 0.47, p < 0.001), median CAR (1.73 vs 1.54, p = 0.002), and median SII index (861.9 vs 730.9, p = 0.015) levels than in those who did not develop NRP. According to multivariant analysis models, SUA/SCr ratio, UAR, CAR and SII index were found to be independent predictors of NRP development (p < 0.05 for all) but only the area under the curve (AUC) for SUA/SCr ratio (AUC = 0.73, p < 0.001) was above the 0.70 proficiency level, performing markedly better than the other evaluated parameters. A SUA/SCr ratio ≥5.34 predicted the NRP with 75% sensitivity and 55% specificity.

Conclusion: SUA/SCr ratio can be used as a reliable marker in prediction the development of NRP in NSTE-ACS patients.

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新定义的非st段抬高急性冠脉综合征患者无血流现象的生物标志物尿酸与肌酐的比值。

背景：本研究旨在探讨新定义的血清尿酸（SUA）与血清肌酐比值（SUA/SCr）是否能预测非st段升高的急性冠脉综合征（NSTE-ACS）患者的无回流现象（NRP）的发展。方法：将研究组分为两组：NRP组和非NRP组。入院时进行全血细胞计数、SUA、血清肌酐、c反应蛋白（CRP）和白蛋白检测。计算所有患者的SUA/SCr、SUA/白蛋白比（UAR）、c反应蛋白/白蛋白比（CAR）和全身免疫炎症指数（SII）值，并评价其与NRP的关系。结果：NRP患者的平均SUA/SCr比（7.19±2.14 vs 5.30±1.70,p p = 0.002）和中位SII指数（861.9 vs 730.9, p = 0.015）水平高于未发生NRP的患者。通过多变量分析模型，发现SUA/SCr比值、UAR、CAR和SII指数是NRP发生的独立预测因子（p p）。结论：SUA/SCr比值可作为预测NSTE-ACS患者NRP发生的可靠指标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta cardiologica 医学-心血管系统

CiteScore

2.50

自引率

12.50%

发文量

115

审稿时长

2 months

期刊介绍： Acta Cardiologica is an international journal. It publishes bi-monthly original, peer-reviewed articles on all aspects of cardiovascular disease including observational studies, clinical trials, experimental investigations with clear clinical relevance and tutorials.