Clinical diagnosis and treatment of G2 laryngeal neuroendocrine tumors.

Abstract

Background: Neuroendocrine tumors are rare malignancies of the head and neck, especially in the larynx. Variations in the location and morphology of laryngeal neuroendocrine tumors result in a lack of standardized clinical treatment.

Objective: This study aimed to examine the treatment and prognosis of laryngeal neuroendocrine tumors in the G2 stage.

Material and methods: Data from eight patients diagnosed with G2 stage laryngeal neuroendocrine tumors, this collection of common clinical cases was analyzed retrospectively to examine the disease's clinical characteristics, treatment, and prognosis affecting the larynx.

Results: Seven cases were supraglottic type and one was a glottic type. These cases were treated with open surgery and CO₂ laser resection with support laryngoscopy, respectively. After surgery, six patients survived, one passed away due to pulmonary metastasis, and one case was lost to follow-up. OS and DSF rates at 1, 3, 5 years were 87.50%, 65.63% and 65.60%, respectively.

Conclusion and significance: The clinical manifestations of G2 stage laryngeal neuroendocrine tumors varied across different locations. Surgical resection of the lesion is the standard treatment. Selection between open neck surgery and support laryngoscope CO₂ laser surgery depends on the tumor's size and location. Following radical surgery, the tumor demonstrates a favorable prognosis.