Jacob N Hirst, Brian R Phung, Bjorn T Johnsson, Junyan He, Brittany Coats, Ashley D Spear
{"title":"Predicting fall parameters from infant skull fractures using machine learning.","authors":"Jacob N Hirst, Brian R Phung, Bjorn T Johnsson, Junyan He, Brittany Coats, Ashley D Spear","doi":"10.1007/s10237-024-01922-7","DOIUrl":null,"url":null,"abstract":"<p><p>When infants are admitted to the hospital with skull fractures, providers must distinguish between cases of accidental and abusive head trauma. Limited information about the incident is available in such cases, and witness statements are not always reliable. In this study, we introduce a novel, data-driven approach to predict fall parameters that lead to skull fractures in infants in order to aid in determinations of abusive head trauma. We utilize a state-of-the-art finite element fracture simulation framework to generate a unique dataset of skull fracture patterns from simulated falls. We then extract features from the resulting fracture patterns in this dataset to be used as input into machine learning models. We compare seven machine learning models on their abilities to predict two fall parameters: impact site and fall height. The results from our best-performing models demonstrate that while predicting the exact fall height remains challenging ( <math><msup><mi>R</mi> <mn>2</mn></msup> </math> 0.27 for the ridge regression model), we can effectively identify potential impact sites ( <math><msup><mi>R</mi> <mn>2</mn></msup> </math> between 0.65 and 0.76 for the random forest regression model). This work not only provides a tool to enhance the ability to assess abuse in cases of pediatric head trauma, but also advocates for advancements in computational models to simulate complex skull fractures.</p>","PeriodicalId":489,"journal":{"name":"Biomechanics and Modeling in Mechanobiology","volume":" ","pages":""},"PeriodicalIF":3.0000,"publicationDate":"2025-01-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Biomechanics and Modeling in Mechanobiology","FirstCategoryId":"5","ListUrlMain":"https://doi.org/10.1007/s10237-024-01922-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOPHYSICS","Score":null,"Total":0}
引用次数: 0
Abstract
When infants are admitted to the hospital with skull fractures, providers must distinguish between cases of accidental and abusive head trauma. Limited information about the incident is available in such cases, and witness statements are not always reliable. In this study, we introduce a novel, data-driven approach to predict fall parameters that lead to skull fractures in infants in order to aid in determinations of abusive head trauma. We utilize a state-of-the-art finite element fracture simulation framework to generate a unique dataset of skull fracture patterns from simulated falls. We then extract features from the resulting fracture patterns in this dataset to be used as input into machine learning models. We compare seven machine learning models on their abilities to predict two fall parameters: impact site and fall height. The results from our best-performing models demonstrate that while predicting the exact fall height remains challenging ( 0.27 for the ridge regression model), we can effectively identify potential impact sites ( between 0.65 and 0.76 for the random forest regression model). This work not only provides a tool to enhance the ability to assess abuse in cases of pediatric head trauma, but also advocates for advancements in computational models to simulate complex skull fractures.
期刊介绍:
Mechanics regulates biological processes at the molecular, cellular, tissue, organ, and organism levels. A goal of this journal is to promote basic and applied research that integrates the expanding knowledge-bases in the allied fields of biomechanics and mechanobiology. Approaches may be experimental, theoretical, or computational; they may address phenomena at the nano, micro, or macrolevels. Of particular interest are investigations that
(1) quantify the mechanical environment in which cells and matrix function in health, disease, or injury,
(2) identify and quantify mechanosensitive responses and their mechanisms,
(3) detail inter-relations between mechanics and biological processes such as growth, remodeling, adaptation, and repair, and
(4) report discoveries that advance therapeutic and diagnostic procedures.
Especially encouraged are analytical and computational models based on solid mechanics, fluid mechanics, or thermomechanics, and their interactions; also encouraged are reports of new experimental methods that expand measurement capabilities and new mathematical methods that facilitate analysis.