Correlation of ACE gene polymorphisms and platelet parameters with morning peak blood pressure in hypertensive patients.

Abstract

Objective: To analyze the relationship between platelet parameters, morning peak blood pressure (MPBP) in hypertensive patients, and angiotensin-converting enzyme (ACE) gene polymorphisms.

Methods: This study included 245 primary hypertensive patients treated between February 2019 and February 2022, who were divided into two groups based on MPBP status: 144 patients with MPBP and 101 without MPBP. Baseline data and early morning fasting blood samples from the antecubital vein were collected. Multiple linear regression was employed to analyze factors influencing MPBP.

Results: Patients with MPBP had significantly higher levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), high-sensitivity C-reactive protein (hs-CRP), and 24-hour systolic (SBP) and diastolic blood pressure (DBP) compared to those without MPBP (all P < 0.05). ACE genotypes were classified as I, DD, and ID, showing significant differences between groups. Patients with MPBP had a significantly higher proportion of the DD genotype and D allele frequency than those without MPBP (P < 0.05). Platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW), and plateletcrit (PCT) were also elevated in MPBP patients all (P < 0.05). Multiple linear regression analysis identified TC, LDL-C, hs-CRP, DD genotype, PLT, MPV, PDW and PCT as independent risk factors for MPBP (all P < 0.05).

Conclusion: In patients with MPBP, platelet parameters and ACE polymorphism, specifically the DD genotype and MPV, are independent risk factors. Monitoring these parameters may help reduce cardiovascular events associated with MPBP.