Construction of curcumin-conjugated pH-responsive lignin-based nanoparticles for alleviating oxidative stress: Stability, antioxidant activity and biocompatibility.
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引用次数: 0
Abstract
Curcumin has a great effect on alleviating oxidative stress, but its poor stability and low biocompatibility limit its application in therapeutic field. In order to overcome these limitations of curcumin, in this study, curcumin was grafted to lignin by esterification, and then prepared into nanoparticles. The results showed that the photothermal stability of curcumin was effectively improved. Moreover, cytotoxicity test showed that Lig-Cur nanoparticles can significantly improve the biocompatibility of curcumin. The ester bonds formed from conjugate also help Lig-Cur nanoparticles have pH-sensitivity in stimulated inflammatory tissue and release curcumin. Finally, by reducing proinflammatory factors, Lig-Cur nanoparticles could effectively scavenge reactive oxygen species (ROS). In addition to alleviating oxidative stress, Lig-Cur nanoparticles were expected to be used as a carrier platform for the treatment of many other inflammatory diseases.
期刊介绍：
The International Journal of Biological Macromolecules is a well-established international journal dedicated to research on the chemical and biological aspects of natural macromolecules. Focusing on proteins, macromolecular carbohydrates, glycoproteins, proteoglycans, lignins, biological poly-acids, and nucleic acids, the journal presents the latest findings in molecular structure, properties, biological activities, interactions, modifications, and functional properties. Papers must offer new and novel insights, encompassing related model systems, structural conformational studies, theoretical developments, and analytical techniques. Each paper is required to primarily focus on at least one named biological macromolecule, reflected in the title, abstract, and text.
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