CBr4-Catalyzed Substituent-Dependent Michael Addition/Paal-Knorr Cyclization of Indole with α,β-Unsaturated Ketones.
IF 3.5
3区 化学
Q2 CHEMISTRY, MULTIDISCIPLINARY
引用次数: 0
Abstract
We report CBr4 catalyzed Michael addition of indole to α,β-unsaturated ketones for the synthesis of β-indolylketones through halogen bonding catalysis. This reaction is compatible with a diverse range of chalcones, including drug-derived chalcones containing sensitive functional groups such as amides, yielding the addition products in good yields. Additionally, 3-indolyl furanoid motifs have been synthesized through the Michael addition followed by Paal-Knorr cyclization by utilizing various unsymmetrical 1,4-enediones in a one-pot process with good yields.
cbr4催化取代基依赖性吲哚与α，β-不饱和酮的Michael加成/Paal-Knorr环化。
我们报道了CBr4催化Michael在α，β-不饱和酮上加成吲哚，通过卤素键催化合成β-吲哚酮。该反应与多种查尔酮兼容，包括含有敏感官能团（如酰胺）的药物衍生查尔酮，以良好的收率产生加成产物。此外，利用各种不对称的1,4-烯二酮，通过Michael加成和Paal-Knorr环化，在一锅法中合成了3-吲哚基类呋喃基序，收率较高。
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来源期刊
Chemistry - An Asian Journal
化学-化学综合
CiteScore
7.00
自引率
2.40%
发文量
535
审稿时长
1.3 months
期刊介绍：
Chemistry—An Asian Journal is an international high-impact journal for chemistry in its broadest sense. The journal covers all aspects of chemistry from biochemistry through organic and inorganic chemistry to physical chemistry, including interdisciplinary topics.
Chemistry—An Asian Journal publishes Full Papers, Communications, and Focus Reviews.
A professional editorial team headed by Dr. Theresa Kueckmann and an Editorial Board (headed by Professor Susumu Kitagawa) ensure the highest quality of the peer-review process, the contents and the production of the journal.
Chemistry—An Asian Journal is published on behalf of the Asian Chemical Editorial Society (ACES), an association of numerous Asian chemical societies, and supported by the Gesellschaft Deutscher Chemiker (GDCh, German Chemical Society), ChemPubSoc Europe, and the Federation of Asian Chemical Societies (FACS).
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