Tumor microenvironment-responsive multinucleated nanocomplexes loaded with carbon dots for combined photothermal/chemodynamic therapy of breast cancer.

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2025-01-16 DOI:10.1002/cmdc.202400983

Zihan Zhu, Yan Zhang, Cui He, Yimin Jin, Wei Bian, Xinjing Tang, Jing Wang

引用次数: 0

Abstract

Low cure rate and high death rate of cancers have seriously threatened human health. The combining multiple therapies is a promising strategy for cancer treatment. In this study, we construct a novel multinucleated nanocomplex loaded with carbon dots (CDs-SA@TAMn) that responds to tumor microenvironment for combined photothermal/chemodynamic cancer therapy. Fluorescence imaging results show that CDs-SA@TAMn can effectively accumulated in tumor sites. In acidic tumor microenvironment, CDs-SA@TAMn will release Mn2+, activating chemodynamic therapy and producing substantial reactive oxygen species (ROS) to kill tumor. Additionally, when irradiated by an 808 nm laser, CDs-SA@TAMn will exert the photothermal effect to realize high performance of cancer hyperthermia treatment. The nanocomplexes feather simple preparation, low toxicity, controlled release and imaging-guided therapy, showcasing the potential of precise and high performance anti-tumor combination therapy in biomedical applications.

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负载碳点的肿瘤微环境响应多核纳米复合物用于光热/化学动力联合治疗乳腺癌。

癌症的低治愈率和高死亡率严重威胁着人类的健康。多种治疗相结合是一种很有前途的癌症治疗策略。在这项研究中，我们构建了一种新型的负载碳点的多核纳米复合物（CDs-SA@TAMn），它对肿瘤微环境有响应，用于光热/化学动力联合治疗癌症。荧光成像结果显示CDs-SA@TAMn能有效地在肿瘤部位积累。在酸性肿瘤微环境中，CDs-SA@TAMn会释放Mn2+，激活化学动力学治疗，产生大量活性氧（ROS）杀死肿瘤。另外，在808 nm激光照射下，CDs-SA@TAMn将发挥光热效应，实现高性能的癌症热疗治疗。该纳米复合物具有制备简单、低毒、控释和成像引导治疗等特点，在生物医学领域具有精确、高效的抗肿瘤联合治疗的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.