Prognostic Significance and Therapeutic Potential of SERPINE1 in Head and Neck Squamous Cell Carcinoma

IF 2.9 2区医学 Q2 ONCOLOGY

Cancer Medicine Pub Date : 2025-01-16 DOI:10.1002/cam4.70605

Changyu Zhu, Heshu Liu, Zhixin Li, Yijun Shi, Jingyang Zhao, Yuping Bai, Qian Chen, Wei Li

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引用次数: 0

Abstract

Background

This study aims to elucidate the expression pattern of SERPINE1, assess its prognostic significance, and explore potential therapeutic drugs targeting this molecule.

Methods and Results

In this study, we delved into the variations in gene mutation, methylation patterns, and expression levels of SERPINE1 in head and neck squamous cell carcinoma (HNSCC) and normal tissues, leveraging comprehensive analyses of The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. The connection between the biological function of the gene and prognosis was scrutinized through immune infiltration and enrichment analyses. Concurrently, we assessed the potential therapeutic value of SERPINE1 through drug sensitivity analysis. It was observed that, particularly in human papillomavirus (HPV) negative HNSCC, SERPINE1 exhibited elevated expression levels, correlating with poorer prognosis. The infiltration levels of eight cell types, such as eosinophils, Tgd, and macrophages, showed a positive correlation with SERPINE1 expression, whereas infiltration levels of four cell types, including cytotoxic cells, B cells, and pDCs, displayed a negative correlation. Furthermore, copy number variations of SERPINE1 were primarily characterized by homologous amplification, positively correlating with its expression, while methylation showed an inverse correlation. The outcomes of drug sensitivity analysis underscored the potential of SERPINE1 as a therapeutic target.

Conclusion

Elevated expression of SERPINE1 in HNSCC is intricately linked with adverse prognostic outcomes and has the potential to influence the immune microenvironment. Subsequent investigations are imperative to fully elucidate the prognostic implications of SERPINE1 as a biomarker and to unlock its therapeutic promise as a target for intervention.

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SERPINE1在头颈部鳞状细胞癌中的预后意义及治疗潜力。

背景：本研究旨在阐明SERPINE1的表达模式，评估其预后意义，并探索针对该分子的潜在治疗药物。方法和结果：在本研究中，我们利用癌症基因组图谱（TCGA）和基因表达Omnibus （GEO）数据集的综合分析，深入研究了头颈部鳞状细胞癌（HNSCC）和正常组织中SERPINE1基因突变、甲基化模式和表达水平的变化。通过免疫浸润和富集分析，探讨了该基因的生物学功能与预后之间的关系。同时，我们通过药敏分析评估SERPINE1的潜在治疗价值。我们观察到，特别是在人乳头瘤病毒（HPV）阴性的HNSCC中，SERPINE1表达水平升高，与较差的预后相关。嗜酸性粒细胞、Tgd和巨噬细胞等8种细胞类型的浸润水平与SERPINE1表达呈正相关，而细胞毒性细胞、B细胞和pDCs等4种细胞类型的浸润水平与SERPINE1表达呈负相关。此外，SERPINE1的拷贝数变化主要以同源扩增为特征，与其表达呈正相关，而甲基化则呈负相关。药物敏感性分析的结果强调了SERPINE1作为治疗靶点的潜力。结论：SERPINE1在HNSCC中的表达升高与不良预后有着复杂的联系，并有可能影响免疫微环境。后续的研究是必要的，以充分阐明SERPINE1作为生物标志物的预后意义，并解锁其作为干预目标的治疗前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Cancer Medicine ONCOLOGY-

CiteScore

5.50

自引率

2.50%

发文量

907

审稿时长

19 weeks

期刊介绍： Cancer Medicine is a peer-reviewed, open access, interdisciplinary journal providing rapid publication of research from global biomedical researchers across the cancer sciences. The journal will consider submissions from all oncologic specialties, including, but not limited to, the following areas: Clinical Cancer Research Translational research ∙ clinical trials ∙ chemotherapy ∙ radiation therapy ∙ surgical therapy ∙ clinical observations ∙ clinical guidelines ∙ genetic consultation ∙ ethical considerations Cancer Biology: Molecular biology ∙ cellular biology ∙ molecular genetics ∙ genomics ∙ immunology ∙ epigenetics ∙ metabolic studies ∙ proteomics ∙ cytopathology ∙ carcinogenesis ∙ drug discovery and delivery. Cancer Prevention: Behavioral science ∙ psychosocial studies ∙ screening ∙ nutrition ∙ epidemiology and prevention ∙ community outreach. Bioinformatics: Gene expressions profiles ∙ gene regulation networks ∙ genome bioinformatics ∙ pathwayanalysis ∙ prognostic biomarkers. Cancer Medicine publishes original research articles, systematic reviews, meta-analyses, and research methods papers, along with invited editorials and commentaries. Original research papers must report well-conducted research with conclusions supported by the data presented in the paper.