Universal Hydrogel Carrier Enhances Bone Graft Success: Preclinical and Clinical Evaluation.

IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Dax Calder, Farshad Oveissi, Simin Maleknia, Tom Huang, Bernard Koong, Terence Abrams, Andrew Oar, Wojciech Chrzanowski, Fariba Dehghani, Ali Fathi
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引用次数: 0

Abstract

Orthopedic, maxillofacial, and complex dentoalveolar bone grafting procedures that require donor-site bone harvesting can be associated with post-surgical complications. There has been widespread adoption of exogenously sourced particulate bone graft materials (BGM) for bone regenerative procedures; however, the particulate nature of these materials may lead to compromised healing outcomes, mainly attributed to structural collapse of the BGM, prolonged tissue healing. In this study, a fully synthetic thermoresponsive hydrogel-based universal carrier matrix (TX) that forms flowable and shapable putties with different BGMs while spatially preserving the particles in a 3D scaffold at the implantation site is introduced. The potential synergistic effect of the carrier is investigated in combination with particulate demineralized bone matrix (DBM) in a standard muscle pouch nude mice model (n = 24) as well as in a rabbit femoral critical-sized cortico-cancellous bone defect model (n = 9). Finally, the clinical usability, safety, and efficacy of the carrier for the delivery of deproteinized bovine bone mineral (DBBM) are evaluated in a controlled clinical trial for extraction socket alveolar ridge preservation (ARP) (n = 11 participants). Overall, the TX carrier improved the delivery of different types of BGMs, maintaining these spatially at the implantation site with minimal inflammatory responses, resulting in favorable bone regenerative outcomes.

通用水凝胶载体提高骨移植成功:临床前和临床评估。
骨科、颌面和复杂的牙槽骨移植手术需要供体部位的骨采集,可能与术后并发症有关。外源颗粒骨移植材料(BGM)已被广泛应用于骨再生手术;然而,这些材料的颗粒性质可能导致愈合结果受损,主要是由于BGM的结构塌陷,组织愈合时间延长。在这项研究中,一种完全合成的热响应性水凝胶通用载体矩阵(TX)被引入,它可以形成具有不同bgm的可流动和可塑形的石膏,同时在植入部位的3D支架中空间上保存颗粒。在标准肌袋裸鼠模型(n = 24)和兔股骨临界尺寸皮质松质骨缺损模型(n = 9)中,研究了载体与颗粒脱矿化骨基质(DBM)联合使用的潜在协同效应。在一项用于拔牙槽槽牙槽嵴保存(ARP)的对照临床试验中(n = 11名参与者)评估了载体递送脱蛋白牛骨矿物质(DBBM)的有效性。总的来说,TX载体改善了不同类型bgm的递送,在植入部位以最小的炎症反应维持这些bgm的空间,从而获得良好的骨再生结果。
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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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