Scalable synthesis of (±)-gregatin A via a 1,3-dipolar cycloaddition strategy.

IF 2.9 3区化学 Q1 CHEMISTRY, ORGANIC

Organic & Biomolecular Chemistry Pub Date : 2025-01-16 DOI:10.1039/d4ob02108h

Yiming Ding, Xiaoli Zhao, Chunlei Qu, Xianwen Long, Yaqiu Zhao, Jun Deng

引用次数: 0

Abstract

A 6-step gram-scale synthesis of the fungal polyketide (±)-gregatin A is described. The synthetic route features an intermolecular 1,3-dipolar cycloaddition, a Mo-mediated disconnection of the isoxazole skeleton, and an acid-mediated deprotection/enamine hydrolysis and hemiketalization cascade.

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1,3偶极环加成策略可扩展合成（±）-gregatin A。

描述了真菌聚酮（±）-gregatin A的6步克级合成。该合成路线具有分子间1,3-偶极环加成，mo介导的异恶唑骨架断开以及酸介导的脱保护/烯胺水解和半iketalization级联反应。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Organic & Biomolecular Chemistry 化学-有机化学

CiteScore

5.50

自引率

9.40%

发文量

1056

审稿时长

1.3 months

期刊介绍： Organic & Biomolecular Chemistry is an international journal using integrated research in chemistry-organic chemistry. Founded in 2003 by the Royal Society of Chemistry, the journal is published in Semimonthly issues and has been indexed by SCIE, a leading international database. The journal focuses on the key research and cutting-edge progress in the field of chemistry-organic chemistry, publishes and reports the research results in this field in a timely manner, and is committed to becoming a window and platform for rapid academic exchanges among peers in this field. The journal's impact factor in 2023 is 2.9, and its CiteScore is 5.5.