Inhibiting Friction-Induced Exogenous Adhesion via Robust Lubricative Core-Shell Nanofibers for High-Quality Tendon Repair.

Abstract

Friction is the trigger cause for excessive exogenous adhesion, leading to the poor self-repair of the tendon. To address this problem, we developed electrospun dual-functional nanofibers with surface robust superlubricated performance and bioactive agent delivery to regulate healing balance by reducing exogenous adhesion and promoting endogenous healing. Coaxial electrospinning and our previous developed in situ robust nanocoating growth techniques were employed to create the lubricative/repairable core-shell structured nanofibrous membrane (L/R-NM). The L/R-NM shell featured a robust coating of the zwitterionic PMPC polymer for strong hydration lubrication to resist exogenous healing. The core could achieve sustained platelet-rich plasma release to promote endogenous healing. Friction tests and cell experiments confirmed L/R-NM's prominent lubricating properties and antiadhesive performance in vitro. Rat tendon injury model evaluation indicated that L/R-NM effectively promotes high-quality tendon repair by inhibiting friction-induced exogenous adhesion and promoting endogenous healing. Therefore, we believe that L/R-NM will open a unique novel horizon for tendon repair.