Intra-articular injection of MOF-based nanomaterials for the treatment of osteoarthritis by modulating the bone microenvironment

IF 23.2 2区材料科学 Q1 MATERIALS SCIENCE, COMPOSITES

Advanced Composites and Hybrid Materials Pub Date : 2025-01-17 DOI:10.1007/s42114-025-01219-y

Bing Tan, Yuhao Zheng, Jie Hao, Qiyuan Yang, Xiao Luo, Qin Li, Xiaoyan Zhang, Jianyuan Ouyang, Jisheng Wang, Zhenming Hu

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引用次数: 0

Abstract

Osteoarthritis (OA) is a degenerative joint disease characterized by cartilage degradation, subchondral bone remodeling, and chronic inflammation. Current therapeutic strategies often fail to address the underlying mechanisms of OA. This study investigates the efficacy of ZIF-8 composite molybdenum (Mo) nanozymes coated by CaCO3 layer (CaCO₃@ZIF@Mo-TA) as a novel therapeutic approach for OA. The nanozymes were characterized using various techniques, including transmission electron microscopy (TEM) and X-ray diffraction (XRD). In vivo studies demonstrated that administration of CaCO₃@ZIF-8@Mo-TA at a dose of 100 mg/kg significantly improved joint health, reduced inflammation, and enhanced cartilage preservation in an OA rat model. Mechanistic studies revealed that the nanozymes exerted antioxidant and anti-inflammatory effects by modulating key signaling pathways, including the NLRP3 inflammasome. These findings suggest that ZIF-8@Mo-TA nanozymes represent a promising therapeutic strategy for OA management.

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基于mof的纳米材料关节内注射通过调节骨微环境治疗骨关节炎

骨关节炎（OA）是一种以软骨退化、软骨下骨重塑和慢性炎症为特征的退行性关节疾病。目前的治疗策略往往不能解决骨性关节炎的潜在机制。本研究探讨了CaCO3层包被的ZIF-8复合钼纳米酶（CaCO3@ZIF@Mo-TA）作为OA治疗新方法的疗效。利用透射电镜（TEM）和x射线衍射（XRD）等技术对纳米酶进行了表征。体内研究表明，CaCO3@ZIF-8@Mo-TA以100 mg/kg的剂量可显著改善OA大鼠模型的关节健康，减少炎症，并增强软骨保存。机制研究表明，纳米酶通过调节包括NLRP3炎性小体在内的关键信号通路发挥抗氧化和抗炎作用。这些发现表明ZIF-8@Mo-TA纳米酶代表了OA管理的一种有前途的治疗策略。

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来源期刊

Advanced Composites and Hybrid Materials Multiple-

CiteScore

26.00

自引率

21.40%

发文量

185

期刊介绍： Advanced Composites and Hybrid Materials is a leading international journal that promotes interdisciplinary collaboration among materials scientists, engineers, chemists, biologists, and physicists working on composites, including nanocomposites. Our aim is to facilitate rapid scientific communication in this field. The journal publishes high-quality research on various aspects of composite materials, including materials design, surface and interface science/engineering, manufacturing, structure control, property design, device fabrication, and other applications. We also welcome simulation and modeling studies that are relevant to composites. Additionally, papers focusing on the relationship between fillers and the matrix are of particular interest. Our scope includes polymer, metal, and ceramic matrices, with a special emphasis on reviews and meta-analyses related to materials selection. We cover a wide range of topics, including transport properties, strategies for controlling interfaces and composition distribution, bottom-up assembly of nanocomposites, highly porous and high-density composites, electronic structure design, materials synergisms, and thermoelectric materials. Advanced Composites and Hybrid Materials follows a rigorous single-blind peer-review process to ensure the quality and integrity of the published work.