18-crown-6 complex cation ionic liquid as an efficient catalyst for the synthesis of 3,4-dihydropyrimidin-2(1H)-one under solvent free condition

IF 2.8 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Research on Chemical Intermediates Pub Date : 2024-12-03 DOI:10.1007/s11164-024-05462-8

Ramesh Mokal, Gopinath Shirole, Vilas Vane, Suresh Jadhavar

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引用次数: 0

Abstract

An efficient method has been developed for the Biginelli synthesis of 3,4-dihydropyrimidin-2(1H)-one analogues by three component reaction of aryl aldehyde, aceto acetic ester and urea/thiourea under the influence of catalytic amount of Crown Ether Complex Cation Ionic Liquid (CECIL) [18-C-6 K]₂[CO₃] under solvent free reaction. This crucial Biginelli transformation in combination with [18-C-6 K]₂[CO₃] catalytic material are offered many advantages for the world of synthetic organic chemistry such as ecofriendly approach, simple thermal condition, easy workup procedure, without use of toxic organic solvents, short reaction time and good yield of the products.

Graphical abstract

Synthesis of 3,4-dihydropyrimidin-2(1H)-one derivatives using [18-C-6 K]₂[CO₃]

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18-冠-6配合物阳离子离子液体在无溶剂条件下催化合成3,4-二氢嘧啶-2(1H)- 1

在冠醚配合物阳离子离子液体（CECIL） [18- c - 6k]2[CO3]的催化量影响下，采用芳醛、乙酰乙酸酯和尿素/硫脲三组分反应，在无溶剂条件下，建立了一种高效的Biginelli合成3,4-二氢嘧啶-2(1H)- 1类似物的方法。这种关键的Biginelli转化与[18- c - 6k]2[CO3]催化材料相结合，为合成有机化学领域提供了许多优点，如生态友好的方法，简单的热条件，易于处理，不使用有毒有机溶剂，反应时间短，产品收率高。图解摘要[18- c - 6k]2[CO3]合成3,4-二氢嘧啶-2(1H)- 1衍生物

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来源期刊

Research on Chemical Intermediates 化学-化学综合

CiteScore

5.70

自引率

18.20%

发文量

229

审稿时长

2.6 months

期刊介绍： Research on Chemical Intermediates publishes current research articles and concise dynamic reviews on the properties, structures and reactivities of intermediate species in all the various domains of chemistry. The journal also contains articles in related disciplines such as spectroscopy, molecular biology and biochemistry, atmospheric and environmental sciences, catalysis, photochemistry and photophysics. In addition, special issues dedicated to specific topics in the field are regularly published.