Seeking optimal non-pharmacological interventions for sarcopenia: a systematic review and network meta-analysis

IF 3.4 3区医学 Q2 GERIATRICS & GERONTOLOGY

Aging Clinical and Experimental Research Pub Date : 2025-01-15 DOI:10.1007/s40520-024-02920-6

Zhenyue Fu, Yajiao Wang, Lu Zhao, Yumeng Li, Qingqiao Song

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引用次数: 0

Abstract

Background

With the acceleration of aging, sarcopenia has become a reality of concern today. This study aimed to evaluate the efficacy of various non-pharmacologic interventions and find the optimal interventions for sarcopenia.

Methods

PubMed, Medline OVID, EMBASE, Scopus, and Cochrane were searched from 1 January 2000 to 25 October 2023, with language restrictions to English. We analyzed the data through the Bayesian network meta-analysis.

Results

Based on the inclusion and exclusion criteria defined by the PICOS principles, we identified 47 eligible clinical trials engaging 4889 individuals (including treatment group = 2835, control group = 2054). The results showed that resistance exercise (low-moderate load) significantly increased muscle mass (skeletal muscle mass and lean body mass) and that exercise plus nutrition improved physical activity indices (handgrip strength, gait speed, TUG test, chair standing).

Conclusion

Resistance exercise (low-moderate load), exercise plus nutrition, and nutritional supplementation (fatty acids, etc.) may be protective against sarcopenia.

Systematic Review Registration https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=474799, ID: CRD4202347479.

查看原文本刊更多论文

寻求肌肉减少症的最佳非药物干预：系统回顾和网络荟萃分析

随着老龄化的加速，肌肉减少症已成为当今人们关注的现实问题。本研究旨在评估各种非药物干预的疗效，并找到治疗肌肉减少症的最佳干预措施。方法检索spubmed、Medline OVID、EMBASE、Scopus和Cochrane，检索时间为2000年1月1日至2023年10月25日。我们通过贝叶斯网络元分析对数据进行分析。结果根据PICOS原则确定的纳入和排除标准，我们确定了47项符合条件的临床试验，涉及4889人（包括治疗组= 2835，对照组= 2054）。结果表明，阻力运动（中低负荷）显著增加了肌肉质量（骨骼肌质量和瘦体质量），运动加营养改善了身体活动指标（握力、步态速度、TUG测试、站立椅）。结论阻力运动（低、中负荷）、运动加营养、营养补充（脂肪酸等）对肌少症有一定的保护作用。系统评价注册https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=474799, ID: CRD4202347479。

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来源期刊

Aging Clinical and Experimental Research 医学-老年医学

CiteScore

7.90

自引率

5.00%

发文量

283

审稿时长

1 months

期刊介绍： Aging clinical and experimental research offers a multidisciplinary forum on the progressing field of gerontology and geriatrics. The areas covered by the journal include: biogerontology, neurosciences, epidemiology, clinical gerontology and geriatric assessment, social, economical and behavioral gerontology. “Aging clinical and experimental research” appears bimonthly and publishes review articles, original papers and case reports.