An analytical review of the therapeutic application of recent trends in MIL-based delivery systems in cancer therapy

IF 5.3 2区化学 Q1 CHEMISTRY, ANALYTICAL

Microchimica Acta Pub Date : 2025-01-16 DOI:10.1007/s00604-024-06944-7

Mohammad Beiranvand, Gholamreza Dehghan

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Abstract

MILs (Materials Institute Lavoisier), as nanocarriers based on metal–organic frameworks (MOFs), are one of the most advanced drug delivery vehicles that are now a major part of cancer treatment research. This review article highlights the key features and components of MIL nanocarriers for the development and improvement of these nanocarriers for drug delivery. Surface coatings are one of the key components of MIL nanocarriers, which play the role of stabilizing the nanocarrier, pH-dependent drug release, increasing the half-life of the drug, and targeting the carrier. MIL nanocarriers have been synthesized mainly by thermal and hydrothermal methods due to their single-step nature and the ability to produce individual crystals with tunable sizes. According to the data available in the literature, MIL-53 and MIL-101 are the best MILs for drug delivery. These MILs have a high ability to release drugs under acidic conditions, indicating their high efficiency compared to other MILs. In addition to drugs, these nanocarriers can also carry fluorescent, photothermal, and photodynamic agents. These agents allow the MIL nanocarriers to benefit from the therapeutic potential of photothermal and photodynamic agents in addition to the therapeutic capacity of the drug. Furthermore, the fluorescent active ingredient gives these nanocarriers a further tracking capability in addition to the inherent tracking capability of MRI. Therefore, MIL nanocarriers as theranostic carriers have the potential to revolutionize both drug delivery and imaging.

Graphical Abstract

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基于mil的给药系统在癌症治疗中的最新应用趋势分析综述

MILs（材料研究所拉瓦锡）作为基于金属有机框架（mof）的纳米载体，是目前最先进的药物递送载体之一，是癌症治疗研究的重要组成部分。本文综述了MIL纳米载体的主要特性和组成，为开发和改进MIL纳米药物载体提供参考。表面涂层是MIL纳米载体的关键组成部分之一，具有稳定纳米载体、ph依赖性药物释放、延长药物半衰期、靶向载体等作用。MIL纳米载体由于其单步性质和能够产生具有可调谐尺寸的单个晶体的能力，主要通过热和水热方法合成。根据文献资料，MIL-53和MIL-101是最适合给药的mil。这些mil在酸性条件下具有较高的药物释放能力，表明它们与其他mil相比具有较高的效率。除了药物外，这些纳米载体还可以携带荧光剂、光热剂和光动力剂。除了药物的治疗能力外，这些药物还允许MIL纳米载体从光热和光动力剂的治疗潜力中受益。此外，荧光活性成分使这些纳米载体除了具有MRI固有的跟踪能力外，还具有进一步的跟踪能力。因此，MIL纳米载体作为治疗载体有可能彻底改变药物输送和成像。图形抽象

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microchimica Acta 化学-分析化学

CiteScore

9.80

自引率

5.30%

发文量

410

审稿时长

2.7 months

期刊介绍： As a peer-reviewed journal for analytical sciences and technologies on the micro- and nanoscale, Microchimica Acta has established itself as a premier forum for truly novel approaches in chemical and biochemical analysis. Coverage includes methods and devices that provide expedient solutions to the most contemporary demands in this area. Examples are point-of-care technologies, wearable (bio)sensors, in-vivo-monitoring, micro/nanomotors and materials based on synthetic biology as well as biomedical imaging and targeting.