Exploring sesquiterpene lactones: structural diversity and antiviral therapeutic insights

IF 3.9 3区 化学 Q2 CHEMISTRY, MULTIDISCIPLINARY
RSC Advances Pub Date : 2025-01-22 DOI:10.1039/D4RA08125K
Yhiya Amen, Gehad Abdelwahab, Ahmed A. Heraiz, Mahmoud Sallam and Ahmed Othman
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引用次数: 0

Abstract

Sesquiterpene lactones (SLs) are a structurally diverse group of secondary metabolites primarily produced by plants, particularly within the Asteraceae family. These compounds play significant roles in plant defense and have been extensively studied for their wide range of biological activities, including antiviral, antimicrobial, anti-inflammatory, and anticancer properties. This review focuses on the biosynthesis, structure–activity relationships, and biological activities of sesquiterpene lactones, with an emphasis on their antiviral potential. SLs exert their antiviral effects by targeting viral entry, replication, and other critical stages of the viral life cycle. Notable examples include guaianolides and germacranolides, which have demonstrated promising activity against viruses such as hepatitis C, influenza, and herpes simplex. This review also emphasizes the potential of sesquiterpene lactones as promising scaffolds for antiviral drug development, positioning these compounds as key candidates in combating viral infections.

Abstract Image

探索倍半萜内酯:结构多样性和抗病毒治疗见解
倍半萜内酯(SLs)是一类结构多样的次生代谢产物,主要由植物产生,特别是在菊科植物中。这些化合物在植物防御中起着重要的作用,并因其广泛的生物活性而被广泛研究,包括抗病毒、抗菌、抗炎和抗癌特性。本文综述了倍半萜内酯的生物合成、构效关系、生物活性等方面的研究进展,并重点介绍了其抗病毒潜力。SLs通过靶向病毒进入、复制和病毒生命周期的其他关键阶段来发挥抗病毒作用。值得注意的例子包括愈创木酚内酯和大黄果内酯,它们已被证明具有抗丙型肝炎、流感和单纯疱疹等病毒的良好活性。本综述还强调了倍半萜内酯作为抗病毒药物开发有前景的支架的潜力,将这些化合物定位为对抗病毒感染的关键候选化合物。
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来源期刊
RSC Advances
RSC Advances chemical sciences-
CiteScore
7.50
自引率
2.60%
发文量
3116
审稿时长
1.6 months
期刊介绍: An international, peer-reviewed journal covering all of the chemical sciences, including multidisciplinary and emerging areas. RSC Advances is a gold open access journal allowing researchers free access to research articles, and offering an affordable open access publishing option for authors around the world.
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