Kamlesh Kumar Nigam, Surabhi Asthana and Mrituanjay D. Pandey
{"title":"Salicylaldimine-functionalized l-phenylalanine-based pseudopeptides: zinc-instructed conformational tuning of self-assembled nanostructures†","authors":"Kamlesh Kumar Nigam, Surabhi Asthana and Mrituanjay D. Pandey","doi":"10.1039/D4LF00251B","DOIUrl":null,"url":null,"abstract":"<p >Pseudopeptidic bioinspired materials are emerging soft matter for recognizing biologically relevant species, supramolecular self-assembled nanostructures, and advanced nanoscience applications. Therefore, we have developed a novel C<small><sub>2</sub></small>-symmetric pseudopeptide using <small>L</small>-phenylalanine amino acid and salicylaldehyde with varying aliphatic spacers. Pseudopeptides show a high selectivity toward Zn(<small>II</small>) ion with significant fluorescence enhancement. The self-assembly exhibits a random spherical nanostructure morphology transformed into a densely packed spherical microstructure morphology after incubating Zn(<small>II</small>) ions through conformational tuning. This zinc-guided rearrangement of self-assembly and interaction with BSA proteins holds significant potential for applications in nanobioscience.</p>","PeriodicalId":101138,"journal":{"name":"RSC Applied Interfaces","volume":" 1","pages":" 167-178"},"PeriodicalIF":0.0000,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/lf/d4lf00251b?page=search","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"RSC Applied Interfaces","FirstCategoryId":"1085","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/lf/d4lf00251b","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Pseudopeptidic bioinspired materials are emerging soft matter for recognizing biologically relevant species, supramolecular self-assembled nanostructures, and advanced nanoscience applications. Therefore, we have developed a novel C2-symmetric pseudopeptide using L-phenylalanine amino acid and salicylaldehyde with varying aliphatic spacers. Pseudopeptides show a high selectivity toward Zn(II) ion with significant fluorescence enhancement. The self-assembly exhibits a random spherical nanostructure morphology transformed into a densely packed spherical microstructure morphology after incubating Zn(II) ions through conformational tuning. This zinc-guided rearrangement of self-assembly and interaction with BSA proteins holds significant potential for applications in nanobioscience.
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