Masterful macrophages: understanding and targeting activation dysfunction in diabetic wounds

IF 6.3 1区医学 Q1 DERMATOLOGY

Burns & Trauma Pub Date : 2025-01-21 DOI:10.1093/burnst/tkaf003

Linian Peng, Gaoxing Luo, Weifeng He, Guangping Liang

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引用次数: 0

Abstract

Diabetes mellitus is a group of chronic metabolic diseases worldwide seriously threatens human health and increases social and economic burden; underlying drivers of impaired healing include uncontrolled inflammation, repeated ischemia–reperfusion injury, and neuropathy alongside infection risks. Macrophages orchestrate standard repair, exhibit sustained classical pro-inflammatory activation in diabetes, disrupting growth factor secretion, angiogenesis, and matrix regulation. Hyperglycemia- mediated advanced glycation end products and reactive oxygen species heighten pattern recognition receptor stimulation, causing reduced alternative macrophage differentiation. Promising immunomodulation approaches redirecting their phenotypes to resolve inflammation and stimulate regeneration provides optimism. We discuss macrophage origination, polarization dynamics, diabetic wound phenotypic imbalance, and critical microenvironmental disruptions perpetuating pathological function. Elucidating specific regulatory nodes upholding their activation states will inform intelligent targeting opportunities. Overall, infiltrating macrophages constitute indispensable yet amenable diabetic wound healing coordinators.

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精通巨噬细胞：了解和靶向糖尿病伤口的激活功能障碍

糖尿病是一种世界性的慢性代谢性疾病，严重威胁人类健康，增加社会经济负担；愈合受损的潜在驱动因素包括不受控制的炎症、反复的缺血-再灌注损伤和伴有感染风险的神经病变。巨噬细胞协调标准修复，在糖尿病中表现出持续的经典促炎激活，破坏生长因子分泌，血管生成和基质调节。高血糖介导的晚期糖基化终产物和活性氧会增强模式识别受体的刺激，导致替代性巨噬细胞分化减少。有希望的免疫调节方法重定向他们的表型来解决炎症和刺激再生提供了乐观。我们讨论巨噬细胞的起源，极化动力学，糖尿病伤口表型失衡，和关键的微环境破坏延续病理功能。阐明维持其激活状态的特定调控节点将为智能靶向机会提供信息。总之，浸润性巨噬细胞是糖尿病伤口愈合不可缺少的协调者。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Burns & Trauma 医学-皮肤病学

CiteScore

8.40

自引率

9.40%

发文量

186

审稿时长

6 weeks

期刊介绍： The first open access journal in the field of burns and trauma injury in the Asia-Pacific region, Burns & Trauma publishes the latest developments in basic, clinical and translational research in the field. With a special focus on prevention, clinical treatment and basic research, the journal welcomes submissions in various aspects of biomaterials, tissue engineering, stem cells, critical care, immunobiology, skin transplantation, and the prevention and regeneration of burns and trauma injuries. With an expert Editorial Board and a team of dedicated scientific editors, the journal enjoys a large readership and is supported by Southwest Hospital, which covers authors'' article processing charges.