Alkylation of Imines with Alkyl Halides under Electrochemical Conditions

IF 4.4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-01-22 DOI:10.1002/adsc.202401527

Tan Zhang, Mengyun Wu, Wenhui Wang, Yingsibing Fan, Ping Liu, Peipei Sun

引用次数: 0

Abstract

An electrochemical protocol for the alkylation of imines was developed by using easily available alkyl halides as the alkyl sources, graphite felt (GF) as anode and zinc plate as cathode. Various substituted imines, alkyl bromides and alkyl iodides were suitable for this reaction and a series of α‐branched amines were obtained in moderate to good yields. This method provides a green way for the addition of imines to avoid the need for metal reagents, chemical oxidants and reductants, which makes it has a good application prospect in drug synthesis.

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电化学条件下亚胺与卤代烃的烷基化反应

以易获得的烷基卤化物为烷基源，石墨毡（GF）为阳极，锌板为阴极，建立了亚胺烷基化的电化学方案。各种取代亚胺、烷基溴化物和烷基碘化物适合于该反应，并以中高收率得到了一系列α‐支胺。该方法为亚胺的添加提供了一条绿色途径，避免了对金属试剂、化学氧化剂和还原剂的需要，在药物合成中具有良好的应用前景。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.