Deuterated Nanopolymers for Renal and Lymphatic Imaging via Quantitative Deuterium MRI

IF 9.6 1区材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Nano Letters Pub Date : 2025-01-22 DOI:10.1021/acs.nanolett.4c03036

Lisa M. Fries, Elton T. Montrazi, Hyla Allouche-Arnon, Felipe Opazo, Amnon Bar-Shir, Lucio Frydman, Stefan Glöggler

引用次数: 0

Abstract

Deuterium (²H) MRI is an emerging tool for noninvasive imaging. We explore the integration of ²H MRI with deuterated multifunctional nanopolymers for deuterated particle imaging (DPI). To this end, amine-terminated G5-polyamidoamine (PAMAM) dendrimers were labeled with deuterated acetyl surface groups, leading to highly ²H-loaded bioparticles, making them ideal for imaging studies. The accumulation of ∼5 nm PAMAM dendrimers in the kidneys could then be seen by ²H MRI with high submillimeter resolution. The natural abundance HDO signal provided an internal concentration reference to these measurements, leading to quantitative dynamic maps showing distinct nanopolymer uptakes within the renal compartments. Further, these nanopolymers allowed us to obtain in vivo maps of activity in the lymph nodes in an inflammatory rodent leg model, demonstrating these deuterated nanopolymers’ potential as a novel class of contrast agents for the quantitative mapping of physiological processes.

Abstract Image

查看原文本刊更多论文

氘化纳米聚合物通过定量氘核磁共振成像用于肾脏和淋巴成像

氘（2H） MRI是一种新兴的无创成像工具。我们探索2H MRI与氘化多功能纳米聚合物的融合，用于氘化粒子成像（DPI）。为此，氨基端g5 -聚氨基胺（PAMAM）树状大分子被氘化乙酰基表面基团标记，导致高2h负载的生物颗粒，使其成为成像研究的理想选择。然后通过高亚毫米分辨率的2H MRI可以看到肾脏中约5 nm PAMAM树状大分子的积累。天然丰度HDO信号为这些测量提供了内部浓度参考，导致定量动态图显示肾间室内不同的纳米聚合物摄取。此外，这些纳米聚合物使我们能够在炎症性啮齿类动物腿部模型中获得淋巴结活动的体内图，证明了这些氘化纳米聚合物作为一种新型对比剂的潜力，可用于生理过程的定量制图。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nano Letters 工程技术-材料科学：综合

CiteScore

16.80

自引率

2.80%

发文量

1182

审稿时长

1.4 months

期刊介绍： Nano Letters serves as a dynamic platform for promptly disseminating original results in fundamental, applied, and emerging research across all facets of nanoscience and nanotechnology. A pivotal criterion for inclusion within Nano Letters is the convergence of at least two different areas or disciplines, ensuring a rich interdisciplinary scope. The journal is dedicated to fostering exploration in diverse areas, including: - Experimental and theoretical findings on physical, chemical, and biological phenomena at the nanoscale - Synthesis, characterization, and processing of organic, inorganic, polymer, and hybrid nanomaterials through physical, chemical, and biological methodologies - Modeling and simulation of synthetic, assembly, and interaction processes - Realization of integrated nanostructures and nano-engineered devices exhibiting advanced performance - Applications of nanoscale materials in living and environmental systems Nano Letters is committed to advancing and showcasing groundbreaking research that intersects various domains, fostering innovation and collaboration in the ever-evolving field of nanoscience and nanotechnology.