Lactobacillus reuteri ZJ617 attenuates metabolic syndrome via microbiota-derived spermidine

IF 14.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Yanfei Ma, Yifan Zhong, Wenjie Tang, Teresa G. Valencak, Jingliang Liu, Zhaoxi Deng, Jiangdi Mao, Daren Liu, Shanshan Wang, Yuhao Wang, Haifeng Wang
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Abstract

Metabolic syndrome (MetS) is a difficult-to-manage disease that poses a significant risk to human health. Here, we show that the supplementation of Lactobacillus reuteri ZJ617 ameliorates symptoms of MetS in mice induced by the high-fat diet. L. reuteri ZJ617 modulates host metabolism by interacting with the microbiome, resulting in the production of spermidine synthesized by the microbiota. L. reuteri ZJ617 serves as a source of substrates for the microbiota to synthesize spermidine, hence preventing the decline of bacteria responsible for spermidine production. Spermidine treatment mimics the metabolic effects of L. reuteri ZJ617, whereas pharmacological inhibition of spermidine biosynthesis in mice abolishes these benefits. Our findings reveal the mechanism by which L. reuteri ZJ617 alleviates MetS symptoms and provide support for its potential use as a probiotic for promoting metabolic health.

Abstract Image

罗伊氏乳杆菌ZJ617通过微生物衍生的亚精胺减轻代谢综合征
代谢综合征(MetS)是一种难以控制的疾病,对人类健康构成重大风险。在这里,我们发现补充罗伊氏乳杆菌ZJ617可以改善高脂肪饮食引起的小鼠MetS症状。罗伊氏乳杆菌ZJ617通过与微生物群相互作用调节宿主代谢,导致微生物群合成亚精胺的产生。罗伊氏乳杆菌ZJ617作为微生物群合成亚精胺的底物来源,从而防止了负责亚精胺生产的细菌的减少。亚精胺处理模拟罗伊氏乳杆菌ZJ617的代谢作用,而小鼠体内亚精胺生物合成的药理学抑制消除了这些益处。我们的研究结果揭示了罗伊氏乳杆菌ZJ617缓解MetS症状的机制,并为其作为促进代谢健康的益生菌的潜在用途提供了支持。
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来源期刊
Nature Communications
Nature Communications Biological Science Disciplines-
CiteScore
24.90
自引率
2.40%
发文量
6928
审稿时长
3.7 months
期刊介绍: Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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