A Stable Zn(II) Metal–Organic Framework as Turn-On and Blue-Shift Fluorescence Sensor for Amino Acids and Dipicolinic Acid in Living Cells or Using Aerosol Jet Printing

IF 4.7 2区化学 Q1 CHEMISTRY, INORGANIC & NUCLEAR

Inorganic Chemistry Pub Date : 2025-01-15 DOI:10.1021/acs.inorgchem.4c05034

Jing Huang, Jin-Jin Wang, Chen Cao, Lei Cao, Teng-Fei Zheng, He-Rui Wen, Sui-Jun Liu

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Abstract

Amino acids and dipicolinic acid (DPA) are important biomarkers for identifying human health. Establishing rapid, accurate, sensitive, and simple assays is essential for disease prevention and early diagnosis. In this work, a novel Zn(II) metal–organic framework (MOF) with the formula {[Zn₅(μ₃–OH)₂(BTDI)₂(dpp)₂]·dpp·4H₂O·2DMF}_n (JXUST-53, where JXUST denotes Jiangxi University of Science and Technology, H₄BTDI = 5,5′-(benzo[c][1,2,5]thiadiazole-4,7-diyl)diisophthalic acid; dpp = 1,3-di(4-pyridyl)propane) was successfully synthesized via a mixed-ligands strategy. JXUST-53 exhibits a three-dimensional (4,10)-connected deh1 topological structure, which remains stable after soaking in aqueous solutions with different pH values (1–12) and organic solvents for at least 24 h, showing high chemical and pH stability. As a potential fluorescence sensor, JXUST-53 can specifically recognize l-threonine (l-Thr), l-histidine (l-His), and DPA in EtOH solutions through fluorescence enhancement and a blue-shift effect. It is worth noting that JXUST-53 is the first MOF-based fluorescence sensor capable of recognizing l-Thr. In addition, the university logo of JXUST with JXUST-53 deposited on it was printed by aerosol jet printing technology, enabling a portable and convenient method for monitoring DPA. More importantly, JXUST-53 has good biocompatibility and low cytotoxicity to sense l-Thr, l-His, and DPA in living cells.

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一种稳定的 Zn(II) 金属有机框架，作为活细胞中或利用气溶胶喷射打印技术检测氨基酸和二羧酸的开启和蓝移荧光传感器

氨基酸和二吡啶酸（DPA）是鉴别人体健康状况的重要生物标志物。建立快速、准确、灵敏、简便的检测方法对疾病预防和早期诊断至关重要。本文设计了一种新型锌（II）金属有机骨架（MOF），分子式为{[Zn5(μ3-OH)2(BTDI)2(dpp)2]·dpp·4H2O·2DMF}n (JXUST-53)，其中JXUST表示江西理工大学，H4BTDI = 5,5′-（苯并[c][1,2,5]噻二唑-4,7-二基）二对苯二甲酸；采用混合配体策略成功合成了DPP = 1,3-二（4-吡啶基）丙烷。JXUST-53具有三维（4,10）连接的deh1拓扑结构，在不同pH值的水溶液（1-12）和有机溶剂中浸泡至少24 h后仍保持稳定，具有较高的化学稳定性和pH稳定性。JXUST-53作为一种潜在的荧光传感器，可以通过荧光增强和蓝移效应特异性识别EtOH溶液中的l-苏氨酸（l-Thr）、l-组氨酸（l-His）和DPA。值得注意的是，JXUST-53是第一个能够识别l-Thr的基于mof的荧光传感器。此外，采用气溶胶喷射打印技术打印了JXUST-53沉积的JXUST-53大学校徽，为DPA监测提供了一种便携、便捷的方法。更重要的是，JXUST-53对活细胞中l-Thr、l-His和DPA具有良好的生物相容性和低的细胞毒性。

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来源期刊

Inorganic Chemistry 化学-无机化学与核化学

CiteScore

7.60

自引率

13.00%

发文量

1960

审稿时长

1.9 months

期刊介绍： Inorganic Chemistry publishes fundamental studies in all phases of inorganic chemistry. Coverage includes experimental and theoretical reports on quantitative studies of structure and thermodynamics, kinetics, mechanisms of inorganic reactions, bioinorganic chemistry, and relevant aspects of organometallic chemistry, solid-state phenomena, and chemical bonding theory. Emphasis is placed on the synthesis, structure, thermodynamics, reactivity, spectroscopy, and bonding properties of significant new and known compounds.