Pregnancy entails a U-shaped trajectory in human brain structure linked to hormones and maternal attachment

IF 14.7 1区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES
Camila Servin-Barthet, Magdalena Martínez-García, María Paternina-Die, Luis Marcos-Vidal, Daniel Martín de Blas, Anna Soler, Olha Khymenets, Daniel Bergé, Gemma Casals, Pilar Prats, Oscar J. Pozo, Clara Pretus, Susana Carmona, Oscar Vilarroya
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Abstract

Growing evidence places the gestational period as a unique moment of heightened neuroplasticity in adult life. In this longitudinal study spanning pre, during, and post pregnancy, we unveil a U-shaped trajectory in gray matter (GM) volume, which dips in late pregnancy and partially recovers during postpartum. These changes are most prominent in brain regions associated with the Default Mode and Frontoparietal Network. The U-shaped trajectory is predominantly linked to gestational factors, as it only presents in gestational mothers and correlates with fluctuations in estrogens over time. Finally, the mother’s mental health status mediates the relationship between postpartum GM volume recovery and maternal attachment at 6 months postpartum. This research sheds light on the complex interplay between hormones, brain development, and behavior during the transition to motherhood. It addresses a significant knowledge gap in the neuroscience of human pregnancy and opens new possibilities for interventions aimed at enhancing maternal health and well-being.

Abstract Image

怀孕期间,人类大脑结构的u型轨迹与激素和母体依恋有关
越来越多的证据表明,妊娠期是成人生活中神经可塑性增强的独特时刻。在这项跨越怀孕前、怀孕期间和怀孕后的纵向研究中,我们揭示了灰质(GM)体积的u形轨迹,该轨迹在怀孕后期下降,并在产后部分恢复。这些变化在与默认模式和额顶叶网络相关的大脑区域最为突出。u型轨迹主要与妊娠因素有关,因为它只出现在妊娠母亲身上,并与雌激素随时间的波动有关。最后,母亲心理健康状况在产后6个月GM体积恢复与母亲依恋的关系中起中介作用。这项研究揭示了荷尔蒙、大脑发育和转变为母亲期间的行为之间复杂的相互作用。它解决了人类妊娠神经科学方面的重大知识缺口,并为旨在加强孕产妇健康和福祉的干预措施开辟了新的可能性。
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来源期刊
Nature Communications
Nature Communications Biological Science Disciplines-
CiteScore
24.90
自引率
2.40%
发文量
6928
审稿时长
3.7 months
期刊介绍: Nature Communications, an open-access journal, publishes high-quality research spanning all areas of the natural sciences. Papers featured in the journal showcase significant advances relevant to specialists in each respective field. With a 2-year impact factor of 16.6 (2022) and a median time of 8 days from submission to the first editorial decision, Nature Communications is committed to rapid dissemination of research findings. As a multidisciplinary journal, it welcomes contributions from biological, health, physical, chemical, Earth, social, mathematical, applied, and engineering sciences, aiming to highlight important breakthroughs within each domain.
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